Sevoflurane Preconditioning plus Postconditioning Decreases Inflammatory Response with Hemodynamic Recovery in Experimental Liver Ischemia Reperfusion

Autor: Eduardo Ryoiti Tatebe, Jonathan Augusto Venceslau Lima, Luiz Augusto Carneiro D'Albuquerque, Emilio E. Abdo, Cinthia Lanchotte, Ana Maria M. Coelho, Camilla Oliveira Mendes, Joel Avancini Rocha-Filho, Bruno Camargo Rocha Paim de Araujo, Estela Regina Ramos Figueira, Flávio Henrique Ferreira Galvão, Mauro Nakatani
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Gastroenterology Research and Practice
Gastroenterology Research and Practice, Vol 2019 (2019)
ISSN: 1687-630X
1687-6121
Popis: Objective. The inhalation anesthetic sevoflurane has presented numerous biological activities, including anti-inflammatory properties and protective effects against tissue ischemic injury. This study investigated the metabolic, hemodynamic, and inflammatory effects of sevoflurane pre- and postconditioning for short periods in the rescue of liver ischemia-reperfusion (IR) injury using a rat model. Materials and Methods. Twenty Wistar rats were divided into four groups: sham group, control ischemia group (partial warm liver ischemia for 45 min followed by 4 h of reperfusion), SPC group (administration of sevoflurane 2.5% for 15 min with 5 min of washout before liver IR), and SPPoC group (administration of sevoflurane 2.5% for 15 min before ischemia and 20 min during reperfusion). Results. All animals showed a decrease in the mean arterial pressure (MAP) and portal vein blood flow during ischemia. After 4 h of reperfusion, only the SPPoC group had MAP recovery. In both the SPC and SPPoC groups, there was a decrease in the ALT level and an increase in the bicarbonate and potassium serum levels. Only the SPPoC group showed an increase in the arterial blood ionized calcium level and a decrease in the IL-6 level after liver reperfusion. Therefore, this study demonstrated that sevoflurane preconditioning reduces hepatocellular injury and acid-base imbalance in liver ischemia. Furthermore, sevoflurane postconditioning promoted systemic hemodynamic recovery with a decrease in inflammatory response.
Databáze: OpenAIRE
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