The search for early markers of plague: evidence for accumulation of solubleYersinia pestisLcrV in bubonic and pneumonic mouse models of disease
| Autor: | Adva Mechaly, Avital Tidhar, David Gur, Gideon Halperin, Sara Cohen, Morly Fisher, Emanuelle Mamroud, Eran Zahavy, Yehuda Flashner |
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| Rok vydání: | 2010 |
| Předmět: |
Pore Forming Cytotoxic Proteins
Serum Microbiology (medical) Pneumonic plague Virulence Factors Immunology Spleen Biology Yersinia Microbiology Bubonic plague Mice Bacterial Proteins Antigen medicine Animals Immunology and Allergy LcrV Antigens Bacterial Plague Yersiniosis General Medicine medicine.disease biology.organism_classification Virology Disease Models Animal Infectious Diseases medicine.anatomical_structure Yersinia pestis Female Bronchoalveolar Lavage Fluid Biomarkers |
| Zdroj: | FEMS Immunology & Medical Microbiology. 59:197-206 |
| ISSN: | 1574-695X 0928-8244 |
| DOI: | 10.1111/j.1574-695x.2010.00687.x |
| Popis: | Markers of the early stages of plague, a rapidly progressing deadly disease, are crucial for enabling the onset of an effective treatment. Here, we show that V-antigen protein (LcrV) is accumulated in the serum of Yersinia pestis-infected mice before bacterial colonization of the spleen and dissemination to blood, in a model of bubonic plague. LcrV accumulation is detected earlier than that of F1 capsular antigen, an established marker of disease. In a mouse model of pneumonic plague, LcrV can be determined in the bronchoalveolar lavage fluid somewhat later than F1, but before dissemination of Y. pestis to the blood. Thus, determination of soluble LcrV is suggested as a potential useful tool for monitoring disease progression in both bubonic and pneumonic plague. Moreover, it may be of particular advantage in cases of infections with F1 nonproducing strains. |
| Databáze: | OpenAIRE |
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