High-Dose 1-(4-Amino-2-methyl-5-pyrimidinyl)-methyl-3-(2-chloroethyl)-3-nitrosourea Hydrochloride (ACNU) with Autologous Bone Marrow Rescue for Patients with Brain Stem Tumors

Autor:	Kimiaki Ikeda, Eiichi Ishii, Nagahide Goya, Sumio Miyazaki, Toshiro Hara, Koichi Inaba, Nobuyuki Yoshida
Rok vydání:	1984
Předmět:	Nitrosourea Pathology medicine.medical_specialty Hydrochloride medicine.medical_treatment Astrocytoma Transplantation Autologous Nitrosourea Compounds chemistry.chemical_compound Prohibitins Humans Medicine Child Bone Marrow Transplantation Chemotherapy Brain Neoplasms business.industry Nimustine General Medicine Autologous bone medicine.disease Combined Modality Therapy Brain stem tumor Kinetics High dose therapy medicine.anatomical_structure chemistry Child Preschool Pediatrics Perinatology and Child Health Surgery Neurology (clinical) Bone marrow business Brain Stem
Zdroj:	Pediatric Neurosurgery. 11:369-374
ISSN:	1423-0305 1016-2291
DOI:	10.1159/000120200
Popis:	4 patients with brain stem tumors were treated with high-dose ACNU with autologous bone marrow rescue. Hematologic and nonhematologic toxicities were not profound. There was objective evidence of response in 2 out of the 4. All were alive for 11–21 months from onset. Safe administration of high-dose ACNU with marrow rescue will warrant further control studies to determine its superiority over conventional doses.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e4ab6e8feabd634ee03335c70afa1b https://doi.org/10.1159/000120200 Zobrazit plný text záznamu