Two-year Carcinogenicity Study in Rats with a Nonnucleoside Reverse Transcriptase Inhibitor
| Autor: | Gwendolyn D. Fate, Gregory L. Finch, Steven Bailey, Daniel Morton, Peter J. Thomford, Christopher Houle, Prashant R. Nambiar, Leland Wayne Dochterman |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Pathology Carcinogenicity Tests Urinary system Kaplan-Meier Estimate Urinalysis urologic and male genital diseases Toxicology Pathology and Forensic Medicine Rats Sprague-Dawley Eating Tubular adenoma Internal medicine Nitriles Animals Medicine Thyroid Neoplasms Molecular Biology Kidney Urinary bladder Dose-Response Relationship Drug business.industry Body Weight Liver Neoplasms Thyroid Cell Biology Transitional epithelium Hepatocellular adenoma medicine.disease Survival Analysis Kidney Neoplasms digestive system diseases Rats Transitional cell carcinoma medicine.anatomical_structure Endocrinology Urinary Bladder Neoplasms Carcinogens Pyrazoles Reverse Transcriptase Inhibitors Female business |
| Zdroj: | Toxicologic Pathology. 43:354-365 |
| ISSN: | 1533-1601 0192-6233 |
| Popis: | Administration of lersivirine, a nonnucleotide reverse transcriptase inhibitor, daily by oral gavage to Sprague-Dawley rats for up to 2 yr was associated with decreased survival, decreased body weights, and an increase in neoplasms and related proliferative lesions in the liver, thyroid, kidney, and urinary bladder. Thyroid follicular adenoma and carcinoma, the associated thyroid follicular hypertrophy/hyperplasia, hepatocellular adenoma/adenocarcinoma, altered cell foci, and hepatocellular hypertrophy were consistent with lersivirine-related induction of hepatic microsomal enzymes. Renal tubular adenoma and renal tubular hyperplasia were attributed to the lersivirine-related exacerbation of chronic progressive nephropathy (CPN), while urinary bladder hyperplasia and transitional cell carcinoma in the renal pelvis and urinary bladder were attributed to urinary calculi. Renal tubular neoplasms associated with increased incidence and severity of CPN, neoplasms of transitional epithelium attributed to crystalluria, and thyroid follicular and hepatocellular neoplasms related to hepatic enzyme induction have low relevance for human risk assessment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|