Mapping main, epistatic and sex-specific QTL for body composition in a chicken populaton divergently selected for low or high growth rate

Autor: Catherine Beaumont, Nengjun Yi, G. A. Ankra-Badu, Elisabeth Le Bihan-Duval, David B. Allison, Larry A. Cogburn, Daniel Shriner, Samuel E. Aggrey, Sandrine Mignon-Grasteau, Michel J. Duclos, Alain Vignal, Frédérique Pitel, Tom E. Porter, Jean Simon
Přispěvatelé: University of Alabama at Birmingham (UAB), University of Georgia [USA], National Institutes of Health, Unité de Recherches Avicoles (URA), Institut National de la Recherche Agronomique (INRA), Laboratoire de Génétique Cellulaire (LGC), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Department of Animal and Avian Sciences, Department of Animal and Food Sciences, University of Delaware [Newark], University of Alabama at Birmingham [ Birmingham] (UAB), This research was supported by grants from the USDA-IFAFS Animal Genome Program to LAC, TEP, SEA and JS (Award Number 00-52100-9614), the Institut National de la Recherche Agronomique (INRA), Analyse du Genome des Animaux d'Elevage (AGENAE) Program and NIH grants GM069430, DK056336, DK076050 and HL072757.
Jazyk: angličtina
Rok vydání: 2010
Předmět:
Male
muscle
[SDV]Life Sciences [q-bio]
gallus gallus
gène marqueur
animal genetic
genetic mapping
Genotype
2. Zero hunger
Genetics
Sex Characteristics
0303 health sciences
education.field_of_study
qtl
Chromosome Mapping
food and beverages
04 agricultural and veterinary sciences
3. Good health
Body Composition
Female
DNA microarray
Research Article
Biotechnology
Meat
lcsh:QH426-470
lcsh:Biotechnology
Quantitative Trait Loci
Population
Abdominal Fat
poulet
Quantitative trait locus
Biology
03 medical and health sciences
Gene mapping
lcsh:TP248.13-248.65
Animals
[INFO]Computer Science [cs]
education
Gene
Crosses
Genetic
030304 developmental biology
composition corporelle
gène
0402 animal and dairy science
Bayes Theorem
Epistasis
Genetic
Sequence Analysis
DNA
040201 dairy & animal science
Sexual dimorphism
lcsh:Genetics
Epistasis
Chickens
Zdroj: BMC Genomics
BMC Genomics, BioMed Central, 2010, 11, online (february), Non paginé. ⟨10.1186/1471-2164-11-107⟩
BMC Genomics february (11, online), Non paginé. (2010)
ResearcherID
BMC Genomics, Vol 11, Iss 1, p 107 (2010)
ISSN: 1471-2164
DOI: 10.1186/1471-2164-11-107⟩
Popis: Background Delineating the genetic basis of body composition is important to agriculture and medicine. In addition, the incorporation of gene-gene interactions in the statistical model provides further insight into the genetic factors that underlie body composition traits. We used Bayesian model selection to comprehensively map main, epistatic and sex-specific QTL in an F2 reciprocal intercross between two chicken lines divergently selected for high or low growth rate. Results We identified 17 QTL with main effects across 13 chromosomes and several sex-specific and sex-antagonistic QTL for breast meat yield, thigh + drumstick yield and abdominal fatness. Different sets of QTL were found for both breast muscles [Pectoralis (P) major and P. minor], which suggests that they could be controlled by different regulatory mechanisms. Significant interactions of QTL by sex allowed detection of sex-specific and sex-antagonistic QTL for body composition and abdominal fat. We found several female-specific P. major QTL and sex-antagonistic P. minor and abdominal fatness QTL. Also, several QTL on different chromosomes interact with each other to affect body composition and abdominal fatness. Conclusions The detection of main effects, epistasis and sex-dimorphic QTL suggest complex genetic regulation of somatic growth. An understanding of such regulatory mechanisms is key to mapping specific genes that underlie QTL controlling somatic growth in an avian model.
Databáze: OpenAIRE
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