Design and synthesis of highly potent and specific dynorphin derivatives for affinity labeling of kappa opioid receptors
| Autor: | Issei Takayanagi, Katsuo Koike, Rei Matsueda |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Stereochemistry
Guinea Pigs Molecular Sequence Data Dynorphin In Vitro Techniques κ-opioid receptor Dynorphins chemistry.chemical_compound Solid-phase synthesis Drug Discovery medicine Animals Amino Acid Sequence Receptor Oligopeptide Affinity labeling Receptors Opioid kappa Dynorphin A Affinity Labels General Chemistry General Medicine Opioid chemistry Biochemistry Drug Design Rabbits medicine.drug |
| Zdroj: | Chemicalpharmaceutical bulletin. 41(7) |
| ISSN: | 0009-2363 |
| Popis: | Dynorphin A derivatives containing S-(3-nitro-2-pyridinesulfenyl)-cysteine(Cys(Npys)) were designed and synthesized for affinity labeling of kappa opioid receptors. Derivatives with Cys(Npys) residue at the 8 position were highly potent and specific to kappa receptors and bound to receptors through disulfide bond formation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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