Dietary intervention in prostate cancer patients: PSA response in a randomized double-blind placebo-controlled study
| Autor: | Jan A. Weststrate, Fritz H. Schröder, Ries Kranse, J. H. M. Blom, Monique C. van Kemenade, Frank H. de Jong, Pieter C. Dagnelie, Lilian Bernadette M. Tijburg |
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| Přispěvatelé: | Epidemiologie, RS: NUTRIM School of Nutrition and Translational Research in Metabolism, Internal Medicine, Urology |
| Rok vydání: | 2005 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Diet therapy Urology urologic and male genital diseases Placebos Prostate cancer Sex hormone-binding globulin Double-Blind Method SDG 3 - Good Health and Well-being Internal medicine medicine Humans Doubling time Testosterone Aged Aged 80 and over biology business.industry Free androgen index Prostatic Neoplasms Middle Aged Prostate-Specific Antigen medicine.disease Crossover study Diet Prostate-specific antigen Treatment Outcome Endocrinology Oncology Androgens Disease Progression biology.protein business |
| Zdroj: | International Journal of Cancer, 113(5), 835-840. Wiley International Journal of Cancer, 113(5), 835-840. Wiley-Liss Inc. |
| ISSN: | 0020-7136 |
| Popis: | The objective of this study was to show or to exclude an effect of dietary supplement on rising prostate-specific antigen (PSA) levels. We have studied the effect of a dietary supplement (verum, administered for 6 weeks) containing plant estrogens, antioxidants, including carotenoids, selenium and other putative prostate cancer inhibiting substances in a randomized placebo-controlled double-blind crossover study in 37 hormonally untreated men with prostate cancer and increasing PSA levels. Outcome measures were changes in the rates of change of serum concentrations of total and free PSA and changes in male sex hormone levels. Male sex hormone levels were significantly lower during the verum phase (DHT: -0.11 nmol/L, p = 0.005; testosterone: -1 nmol/L, p = 0.02). Total PSA doubling time was unaffected. Free PSA, which increased during the placebo phase (average doubling time of 68 weeks), decreased during the verum period (average half-life of 13 weeks; p = 0.02). In those men in whom the free androgen index decreased (21 out of 32), a significant decrease in the slopes of both total and free PSA was observed (p = 0.04). Overall total PSA doubling times did not increase significantly during verum. However, the study demonstrates that this dietary intervention reduces DHT and testosterone levels and increases free PSA doubling time (and total PSA doubling time in a relevant subgroup). If future studies confirm that these observations translate into a slowing of disease progression, a dietary intervention may become an attractive option for prostate cancer treatment and prevention. |
| Databáze: | OpenAIRE |
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