The role of hyperinsulinemia as a cardiometabolic risk factor independent of obesity in polycystic ovary syndrome
| Autor: | Orsolya Karola Csenteri, Sándor Gődény, János Sándor, Edit Kalina, Harjit Pal Bhattoa |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism Klinikai orvostudományok Young Adult 03 medical and health sciences 0302 clinical medicine Endocrinology Insulin resistance Risk Factors Hyperinsulinism Internal medicine Hyperinsulinemia Humans Medicine Obesity 030219 obstetrics & reproductive medicine business.industry Insulin nutritional and metabolic diseases Obstetrics and Gynecology Orvostudományok medicine.disease Polycystic ovary Cardiovascular Diseases Homeostatic model assessment Female lipids (amino acids peptides and proteins) Insulin Resistance business Body mass index Dyslipidemia Polycystic Ovary Syndrome |
| Popis: | The aim of this study was to utilize various insulin resistance measuring methods to determine whether insulin resistance and other parameters impact the serum lipid levels of polycystic ovary syndrome (PCOS) patients and how the serum lipid levels in these patients are affected by the body mass index (BMI). Our dataset included patients between the ages of 16 and 42 (N = 228) from the outpatient endocrinology clinic of the Department of Obstetrics and Gynecology, who demonstrated increased hair growth and bleeding disorders and came for a routine oral glucose tolerance test (OGTT). Differences in the serum lipid levels were evaluated by t-test and linear regression analysis after adjusting for BMI. A stepwise regression model was constructed to evaluate the influence of each variable on the lipid levels. In PCOS patients, we found that dyslipidemia is more prevalent among hyperinsulinemic women compared with normoinsulinemic women, even after normalizing for BMI. PCOS patients with insulin resistance, determined by the insulin sensitivity index (ISI) method, showed more significant lipid abnormalities such as low high-density lipoprotein (HDL) and apo-A levels and high total cholesterol, low-density lipoprotein (LDL) and apo-B levels than if insulin resistance (IR) determination was based on insulin level or homeostatic model assessment (HOMA). |
| Databáze: | OpenAIRE |
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