Proteomics analysis of the hypothalamus in spontaneously hypertensive rats treated with twirling reinforcing manipulation, twirling reducing manipulation or electroacupuncture
| Autor: | Jiaojuan Wu, Kibeum Park, Zhi Ji, Tianxiao Zeng, Jiao Sun, Qingguo Liu, Kaimin Li, Xiaomin Hao, Xudong Zhang, Jingrong Liang |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.drug_class Electroacupuncture medicine.medical_treatment Bioinformatics 03 medical and health sciences proteomics 0302 clinical medicine Immunology and Microbiology (miscellaneous) Neurotrophic factors Acupuncture Medicine hypothalamus Antihypertensive drug Oncogene business.industry Articles General Medicine Molecular medicine parallel reaction monitoring 030104 developmental biology Hypothalamus 030220 oncology & carcinogenesis Proteome spontaneously hypertensive rats business acupuncture |
| Zdroj: | Experimental and Therapeutic Medicine |
| ISSN: | 1792-1015 1792-0981 |
| DOI: | 10.3892/etm.2021.9812 |
| Popis: | Hypertension is one of the primary risk factors for cardiovascular diseases. Numerous proteins serve a critical role in hypertension. Acupuncture has been widely used as a treatment for hypertension in China. The results of the current study suggested that electroacupuncture (EA), twirling reinforcing manipulation (TRFM) and twirling reducing manipulation (TRDM) may be useful in the treatment of hypertension. Additionally, proteome analysis of spontaneously hypertensive rats treated with EA, TRFM and TRDM was performed. There were 117 (EA group), 61 (TRFM group) and 86 (TRDM group) differentially expressed proteins (DEPs) identified in the respective experimental groups compared with the model group. Moreover, parallel reaction monitoring assays were used to validate the reliability of the DEPs. The majority of the results were consistent with previous proteomics results, in particular that for expression of neudesin neurotrophic factor (NENF). NENF may potentially represent an antihypertensive drug target. |
| Databáze: | OpenAIRE |
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