Hippocampal subfield volumetry in mild cognitive impairment, Alzheimer's disease and semantic dementia☆
| Autor: | Francis Eustache, Renaud La Joie, Vincent de La Sayette, Stéphanie Egret, Audrey Perrotin, Gaël Chételat, Serge Belliard, Béatrice Desgranges, Loïc Doeuvre |
|---|---|
| Přispěvatelé: | Neuropsychologie cognitive et neuroanatomie fonctionnelles de la mémoire humaine, Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Neurologie [CHU Caen], Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Service de Neurologie [Rennes] = Neurology [Rennes], CHU Pontchaillou [Rennes], This work was supported by the Fondation Plan Alzheimer (Alzheimer Plan 2008-2012), Programme Hospitalier de Recherche Clinique (PHRC National 2011), Agence Nationale de la Recherche (ANR LONGVIE 2007), Région Basse Normandie, and Institut National de la Santé et de la Recherche Médicale (INSERM), including the Inserm-Liliane Bettencourt School (MD-PhD Program)., Eustache, Francis, Service de Neurologie [Rennes], Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes] |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
MRI Magnetic resonance imaging Cognitive Neuroscience Aβ β-amyloid PET Positon Emission Tomography Semantic dementia Disease Hippocampal formation Article CA1 aMCI amnestic Mild Cognitive Impairment 03 medical and health sciences 0302 clinical medicine Atrophy Mild Cognitive Impairment (MCI) Internal medicine medicine Radiology Nuclear Medicine and imaging [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Magnetic resonance imaging (MRI) Mild cognitive impairment (MCI) HC healthy controls 10. No inequality 030304 developmental biology AUC Area Under the receiver operating characteristic Curve 0303 health sciences Receiver operating characteristic NFT neurofibrillary tangles Subiculum SUVr Standardized Uptake Value ratio Alzheimer's disease medicine.disease Hippocampal subfields ROC receiver operating characteristic Neurology nervous system Cardiology [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Neurology (clinical) Analysis of variance AD Alzheimer's disease ANOVA Analysis of variance Psychology Neuroscience TIV Total intracranial volume 030217 neurology & neurosurgery |
| Zdroj: | NeuroImage : Clinical Neuroimage-Clinical Neuroimage-Clinical, 2013, 3, pp.155-62. ⟨10.1016/j.nicl.2013.08.007⟩ Neuroimage-Clinical, Elsevier, 2013, 3, pp.155-62. ⟨10.1016/j.nicl.2013.08.007⟩ |
| ISSN: | 2213-1582 |
| DOI: | 10.1016/j.nicl.2013.08.007⟩ |
| Popis: | Background Hippocampal atrophy is a well-known feature of Alzheimer's disease (AD), but sensitivity and specificity of hippocampal volumetry are limited. Neuropathological studies have shown that hippocampal subfields are differentially vulnerable to AD; hippocampal subfield volumetry may thus prove to be more accurate than global hippocampal volumetry to detect AD. Methods CA1, subiculum and other subfields were manually delineated from 40 healthy controls, 18 AD, 17 amnestic Mild Cognitive Impairment (aMCI), and 8 semantic dementia (SD) patients using a previously developed high resolution MRI procedure. Non-parametric group comparisons and receiver operating characteristic (ROC) analyses were conducted. Complementary analyses were conducted to evaluate differences of hemispheric asymmetry and anterior-predominance between AD and SD patients and to distinguish aMCI patients with or without β-amyloid deposition as assessed by Florbetapir-TEP. Results Global hippocampi were atrophied in all three patient groups and volume decreases were maximal in the CA1 subfield (22% loss in aMCI, 27% in both AD and SD; all p Highlights • Using 3 T MRI, hippocampal subfields were measured in aMCI, AD and SD and controls. • CA1 atrophy was found to be predominant in all patient groups. • CA1 volume was the best discriminating measure between controls and aMCI patients. • AD and SD differed in asymmetry and anterior-predominance, not in subfield atrophy. |
| Databáze: | OpenAIRE |
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