Cell type ontologies of the Human Cell Atlas
| Autor: | Ed S. Lein, Chuan Xu, Maria Keays, Sarah A. Teichmann, Peter V. Kharchenko, David Osumi-Sutherland, Adam P. Levine, Aviv Regev |
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| Rok vydání: | 2021 |
| Předmět: |
Cell type
Computer science Cells Ontology (information science) 03 medical and health sciences Atlases as Topic 0302 clinical medicine Data Mining Humans Profiling (information science) Cell Lineage Disease 030304 developmental biology 0303 health sciences Cellular composition Atlas (topology) High-Throughput Nucleotide Sequencing Reference cell Genomics Cell Biology Human cell Data science Cell biology Systems Integration Gene Ontology Phenotype Biological Ontologies Single-Cell Analysis Transcriptome Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | Nature Cell Biology. 23:1129-1135 |
| ISSN: | 1476-4679 1465-7392 |
| DOI: | 10.1038/s41556-021-00787-7 |
| Popis: | Massive single-cell profiling efforts have accelerated our discovery of the cellular composition of the human body while at the same time raising the need to formalize this new knowledge. Here, we discuss current efforts to harmonize and integrate different sources of annotations of cell types and states into a reference cell ontology. We illustrate with examples how a unified ontology can consolidate and advance our understanding of cell types across scientific communities and biological domains. |
| Databáze: | OpenAIRE |
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