B+-Thalassemia Trait: Hematologic and Hemoglobin Synthesis Studies
| Autor: | S. Pootrakul, S. Assawamunkong, S. Na-Nakorn |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Genetics
Heterozygote medicine.medical_specialty Biochemistry (medical) Clinical Biochemistry Hemoglobin synthesis Heterozygote advantage Globin chain Hematology Biology Peripheral blood Globins Loss of heterozygosity Hemoglobins Endocrinology Beta thalassemia trait Internal medicine medicine Humans Thalassemia Globin Hemoglobin Genetics (clinical) |
| Zdroj: | Hemoglobin. 1:75-83 |
| ISSN: | 1532-432X 0363-0269 |
| DOI: | 10.3109/03630267609031023 |
| Popis: | In Thailand, two types of high Hb A2-beta-thalassemia genes: beta0-thalassemia (beta0-thal) or classical beta-thalassemia and beta+-thalassemia (beta+-thal) or mild beta-thalassemia exist. This study presents hematologic data and globin chain synthesis in peripheral blood of the genuine beta+-thal heterozygotes in comparison with those of the beta0-thal heterozygotes. Thirty individuals of Thai and Chinese extraction with the beta+-thal heterozygosity were hematologically examined. The hematologic means of hemoglobin concentration, MCV, MCH, MCHC, Hb A2 and alkali denaturation hemoglobin of the beta+-thal traits were, 11.7 g%, 67.8 mu3, 21.5 gammagamma, 32.1%, 4.94% and 1.20% respectively. These were not statistically different from those of the beta0-thal traits of our previous study(1). The globin chain synthesis in reticulocytes were performed by incorporation of 3H-Leucine for 3 hours. The mean of total radioactivity alpha/beta ratio in 11 normal controls was 1.07 +/- SD 0.03. The mean of alpha/beta ratio in 9 beta+-thal traits was 2.03 +/- SD 0.10 which was significantly different from that in 7 beta0-thal traits of 2.28 +/- SD 0.07. Our globin chain synthesis thus appears to be helpful of discriminating the beta+-thal trait from the beta0-thal trait. |
| Databáze: | OpenAIRE |
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