Role of fibrinolytic parameters and plasminogen activator inhibitor 1 (PAI-1) promoter polymorphism on premature atherosclerosis in SLE patients

Autor: N Tasdelen, Nilgun Mutlu, Muge Bicakcigil, Sule Yavuz, DA Tasan
Přispěvatelé: Bicakcigil, M., Tasan, D.A., Tasdelen, N., Mutlu, N., Yavuz, S., Yeditepe Üniversitesi
Rok vydání: 2011
Předmět:
Adult
Male
medicine.medical_specialty
Genotype
Promoter polymorphism
PAI-1
Tissue plasminogen activator
Carotid Intima-Media Thickness
chemistry.chemical_compound
Rheumatology
Antigen
Gene Frequency
Polymorphism (computer science)
Risk Factors
Internal medicine
Plasminogen Activator Inhibitor 1
medicine
Humans
Lupus Erythematosus
Systemic
tPA
Carotid Stenosis
Promoter Regions
Genetic
systemic lupus erythematosus (SLE)
DNA Primers
fibrinolytic parameters
Polymorphism
Genetic
Base Sequence
business.industry
Fibrinolysis
PAI-1 polymorphism
Middle Aged
Atherosclerosis
Coronary Vessels
Takayasu Arteritis
Endocrinology
Premature atherosclerosis
chemistry
Plasminogen activator inhibitor-1
Case-Control Studies
Tissue Plasminogen Activator
Female
Gene polymorphism
atherosclerosis
business
Plasminogen activator
medicine.drug
Zdroj: Lupus. 20(10)
ISSN: 1477-0962
Popis: Premature atherosclerosis has been recognized as a major co-morbid condition in systemic lupus erythematosus (SLE). In this study, we aimed to investigate the effect of tPA (tissue plasminogen activator) and PAI-1 (plasminogen activator inhibitor) antigen concentrations and 4G/5G polymorphism of the PAI-1 gene on the development of atherosclerosis in SLE patients. One hundred and six SLE patients, 28 Takayasu arteritis (TA) patients and 98 healthy control subjects (HCs) were studied. PAI-1 and tPA antigen levels were measured by ELISA method. PAI-1 gene polymorphism was determined by using allele-specific PCR method. SLE patients had a significantly higher frequency (22.6%) of plaque (p = 0.01) and higher IMT (p=0.04) compared with HCs respectively. Only age at disease onset was associated with plaque formation in multivariate regression analysis (p = 0.001). Plasma tPA ag levels in SLE patients were significantly higher compared with HCs (p = 0.005) and PAI-1 ag levels were significantly higher compared with TA patients (p = 0.03). There were no significant differences between study groups in both genotype distribution and allele frequencies of PAI-1 gene, but SLE patients with 4G/4G genotype had higher IMT (p = 0.02) calcium scoring (p = 0.006) compared with 4G5G/5G5G genotypes. The present study suggests that measuring fibrinolytic parameters would have little additional benefit beyond traditional and novel risk factors in predicting coronary artery disease (CAD). © The Author(s), 2011. Marmara Üniversitesi: SAG-B-060308-0023 RAED AD-73 This work was supported by Marmara University (SAG-B-060308-0023) and the Society for Research and Education in Rheumatology (RAED AD-73).
Databáze: OpenAIRE
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