Corneal nerve fiber involvement in chronic inflammatory demyelinating polyneuropathy

Autor: Ezgi Keskiner-Ozturk, Semra Akkaya-Turhan, Ebru Toker, Kayihan Uluc, Hande Alibas, Tulin Tanridag, Pinar Kahraman-Koytak
Přispěvatelé: KESKİNER ÖZTÜRK E., AKKAYA TURHAN S., Toker E., Uluc K., Alibas H., Tanridag T., Kahraman-Koytak P.
Jazyk: angličtina
Rok vydání: 2023
Předmět:
İnsan Bilgisayar Etkileşimi
Bilişsel Sinirbilim
NEUROSCIENCES
NEUROSCIENCE & BEHAVIOR
SİNİR BİLİMİ
Genel Sinirbilim
Sağlık Bilimleri
Neuropathic pain
Clinical Medicine (MED)
Nöroloji (klinik)
Nöroloji
SOCIETY GUIDELINE
Small fber
Klinik Tıp (MED)
Inflammatory polyneuropathy
MARIE-TOOTH DISEASE
DAMAGE
Klinik Tıp
Temel Bilimler
General Neuroscience
Life Sciences
General Medicine
Infammatory polyneuropathy
Sensory Systems
Tıp
Psychiatry and Mental health
Neurology
Physical Sciences
Sinirbilim ve Davranış
Medicine
Natural Sciences
Sinirbilim (çeşitli)
Cognitive Neuroscience
Confocal confocal microscopy
Neuroscience (miscellaneous)
Life Sciences (LIFE)
Dermatology
CLINICAL NEUROLOGY
DIAGNOSIS
Cellular and Molecular Neuroscience
Developmental Neuroscience
Small fiber
Yaşam Bilimleri
Health Sciences
CONFOCAL MICROSCOPY
Hücresel ve Moleküler Sinirbilim
KLİNİK NÖROLOJİ
Internal Medicine Sciences
Dahili Tıp Bilimleri
CLINICAL MEDICINE
Duyusal Sistemler
DYSFUNCTION
Human-Computer Interaction
Fizik Bilimleri
Yaşam Bilimleri (LIFE)
POLYRADICULONEUROPATHY REPORT
Corneal confocal microscopy
Gelişimsel Sinirbilim
Neurology (clinical)
PERIPHERAL NEUROPATHY
Popis: BackgroundDespite the primary myelin-related pathophysiology, small fiber neuropathy (SFN) and axonal degeneration are also considered to be involved and associated with disabling symptoms and impaired quality of life in chronic inflammatory demyelinating polyneuropathy (CIDP). Demonstration of SFN usually requires complex or invasive investigations.ObjectsIn vivo corneal confocal microscopy (IVCCM) has evolved as a non-invasive, easily applied method for quantification of small fiber involvement in peripheral nerve disorders. We aimed to investigate the potential role of IVCCM in CIDP.MethodsIn this cross-sectional study, 15 patients with CIDP underwent assessment with clinical disability scales, neuropathic pain (NP) and autonomic symptom questionnaires, nerve conduction studies, and IVCCM. IVCCM parameters were analyzed and compared to those from 32 healthy controls.ResultsCorneal nerve fiber density (CNFD) and corneal nerve fiber length (CNFL) were significantly decreased in the CIDP group, compared to those in controls (p = 0.03 and p = 0.024, respectively). Langerhans cells and fiber tortuosity were increased in CIDP patients (p = 0.005 and p = 0.001, respectively). IVCCM parameters were significantly lower in patients with NP compared to those in patients without NP.ConclusionIVCCM shows promise as a non-invasive complementary biomarker in the assessment of demyelinating polyneuropathies, providing insights into the potential pathophysiology of these non-length-dependent neuropathies.
Databáze: OpenAIRE
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