Effects of Different Levels of Intravenous α-Linolenic Acid and Supplemental Breast Milk on Red Blood Cell Docosahexaenoic Acid in Very Low Birth-Weight Infants
| Autor: | Rhodes Pg, Reddy Ns, Carlson Se, Downing G |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
medicine.medical_specialty
Docosahexaenoic Acids Linolenic Acids Phospholipid Physiology Breast milk Enteral administration Random Allocation chemistry.chemical_compound Oral administration Humans Medicine Infusions Intravenous Milk Human business.industry alpha-Linolenic acid Erythrocyte Membrane Infant Newborn Gastroenterology alpha-Linolenic Acid food and beverages Infant Low Birth Weight Surgery Low birth weight Parenteral nutrition chemistry Docosahexaenoic acid Pediatrics Perinatology and Child Health Infant Food Parenteral Nutrition Total lipids (amino acids peptides and proteins) medicine.symptom business Infant Premature |
| Zdroj: | Journal of Pediatric Gastroenterology and Nutrition. 13:67-71 |
| ISSN: | 0277-2116 |
| Popis: | Preterm infants weighing less than 1,500 g were started on total parenteral nutrition (TPN) if unable to tolerate full enteral feedings. They were randomly assigned to receive intravenous lipids containing either 4.2 or 9.0% alpha-linolenic acid to assess the effect on red blood cell (RBC) phospholipid polyenoic fatty acid composition, particularly docosahexaenoic acid (22:6n3) (DHA). DHA ultimately comes from alpha-linolenic acid (18:3n3), although there is evidence in human preterm infants that they require preformed DHA. After 1 week of TPN, infants were started on gradually increasing amounts of enteral feeding, breast milk, if elected by mothers, or premature milk formula (Preemie Enfamil). RBC phospholipid fatty acids were measured weekly. Results were evaluated comparing samples from week 1 and week 6. Supplying 9% alpha-linolenic acid in intravenous lipids did not prevent a fall in DHA by 6 weeks; however, infants receiving breast-milk feeding did not have a significant decrease in DHA. Studies are needed to evaluate supplying DHA in intravenous lipids. |
| Databáze: | OpenAIRE |
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