The S100B Protein and Partners in Adipocyte Response to Cold Stress and Adaptive Thermogenesis: Facts, Hypotheses, and Perspectives
| Autor: | Jacques Baudier, Benoit J. Gentil |
|---|---|
| Přispěvatelé: | Institut de Biologie du Développement de Marseille (IBDM), Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Centre National de la Recherche Scientifique (CNRS), McGill University = Université McGill [Montréal, Canada] |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
p53 [SDV]Life Sciences [q-bio] lcsh:QR1-502 Adipose tissue Review S100 Calcium Binding Protein beta Subunit enlargosome Biochemistry ATAD3A lcsh:Microbiology RAGE (receptor) annexin2 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Adipocyte Adipocytes Animals Humans Secretion CYP2E1 Molecular Biology biology Endoplasmic reticulum Cold-Shock Response S100A10 Thermogenesis AHNAK Cell biology 030104 developmental biology chemistry 030220 oncology & carcinogenesis biology.protein RPTPσ exocytosis S100 proteins Intracellular |
| Zdroj: | Biomolecules Biomolecules, MDPI, 2020, 10, ⟨10.3390/biom10060843⟩ Biomolecules, 2020, 10, ⟨10.3390/biom10060843⟩ Biomolecules, Vol 10, Iss 843, p 843 (2020) |
| ISSN: | 2218-273X |
| Popis: | International audience; In mammals, adipose tissue is an active secretory tissue that responds to mild hypothermia and as such is a genuine model to study molecular and cellular adaptive responses to cold-stress. A recent study identified a mammal-specific protein of the endoplasmic reticulum that is strongly induced in the inguinal subcutaneous white adipocyte upon exposure to cold, calsyntenin 3β (CLSTN3β). CLSTN3β regulates sympathetic innervation of thermogenic adipocytes and contributes to adaptive non-shivering thermogenesis. The calcium-and zinc-binding S100B is a downstream effector in the CLSTN3β pathways. We review, here, the literature on the transcriptional regulation of the S100b gene in adipocyte cells. We also rationalize the interactions of the S100B protein with its recognized or hypothesized intracellular (p53, ATAD3A, CYP2E1, AHNAK) and extracellular (Receptor for Advanced Glycation End products (RAGE), RPTPσ) target proteins in the context of adipocyte differentiation and adaptive thermogenesis. We highlight a chaperon-associated function for the intracellular S100B and point to functional synergies between the different intracellular S100B target proteins. A model of non-classical S100B secretion involving AHNAK/S100A10/annexin2-dependent exocytosis by the mean of exosomes is also proposed. Implications for related areas of research are noted and suggestions for future research are offered. |
| Databáze: | OpenAIRE |
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