Oxidative stress marker aberrations in children with autism spectrum disorder: a systematic review and meta-analysis of 87 studies (N = 9109)
Autor: | Lei Chen, Xiao Mao, Hua Liu, Yong Cheng, Lue-Ning Gui, Xiao-Jie Shi, Hua Wang |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Vitamin medicine.medical_specialty Homocysteine Autism Spectrum Disorder medicine.medical_treatment medicine.disease_cause Molecular neuroscience Article lcsh:RC321-571 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound 0302 clinical medicine Internal medicine mental disorders medicine Vitamin D and neurology Humans Vitamin B12 Child lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Biological Psychiatry business.industry Vitamin E Glutathione Autism spectrum disorders Malondialdehyde Psychiatry and Mental health Oxidative Stress 030104 developmental biology Endocrinology chemistry business Oxidation-Reduction 030217 neurology & neurosurgery Oxidative stress Biomarkers |
Zdroj: | Translational Psychiatry, Vol 11, Iss 1, Pp 1-10 (2021) Translational Psychiatry |
ISSN: | 2158-3188 |
Popis: | There is increasing awareness that oxidative stress may be implicated in the pathophysiology of autism spectrum disorder (ASD). Here we aimed to investigate blood oxidative stress marker profile in ASD children by a meta-analysis. Two independent investigators systematically searched Web of Science, PubMed, and Cochrane Library and extracted data from 87 studies with 4928 ASD children and 4181 healthy control (HC) children. The meta-analysis showed that blood concentrations of oxidative glutathione (GSSG), malondialdehyde, homocysteine, S-adenosylhomocysteine, nitric oxide, and copper were higher in children with ASD than that of HC children. In contrast, blood reduced glutathione (GSH), total glutathione (tGSH), GSH/GSSG, tGSH/GSSG, methionine, cysteine, vitamin B9, vitamin D, vitamin B12, vitamin E, S-adenosylmethionine/S-adenosylhomocysteine, and calcium concentrations were significantly reduced in children with ASD relative to HC children. However, there were no significance differences between ASD children and HC children for the other 17 potential markers. Heterogeneities among studies were found for most markers, and meta-regressions indicated that age and publication year may influence the meta-analysis results. These results therefore clarified blood oxidative stress profile in children with ASD, strengthening clinical evidence of increased oxidative stress implicating in pathogenesis of ASD. Additionally, given the consistent and large effective size, glutathione metabolism biomarkers have the potential to inform early diagnosis of ASD. |
Databáze: | OpenAIRE |
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