Amino acid concentrations and selected enzyme activities in rat auditory, olfactory, and visual systems
| Autor: | Donald A. Godfrey, Judy A. Parli, C. David Ross |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_specialty
Taurine Glutamic Acid Biology Biochemistry Malate dehydrogenase Choline O-Acetyltransferase Cellular and Molecular Neuroscience chemistry.chemical_compound Glutaminase Malate Dehydrogenase Internal medicine Lactate dehydrogenase medicine Animals Tissue Distribution Aspartate Aminotransferases Amino Acids Visual Cortex Auditory Cortex chemistry.chemical_classification Aspartic Acid L-Lactate Dehydrogenase Glutamate receptor Olfactory Pathways General Medicine Rats Amino acid Glutamine Endocrinology chemistry Glycine |
| Zdroj: | Neurochemical Research. 20:1483-1490 |
| ISSN: | 1573-6903 0364-3190 |
| DOI: | 10.1007/bf00970598 |
| Popis: | Homogenates of specific brain regions of three sensory systems (auditory, olfactory, and visual) were prepared from pigmented Long-Evans Hooded rats and assayed for amino acid concentrations and activities of glutaminase, aspartate aminotransferase (total, cytosolic, and, by difference, mitochondrial), malate dehydrogenase, lactate dehydrogenase, and choline acetyltransferase. Comparing the quantitative distributions among regions revealed significant correlations between AAT and aspartate, between glutaminase and glutamate, between glutamate and glutamine, and between AAT plus glutaminase, or glutaminase alone, and the sum of aspartate, glutamate, and GABA, suggesting a metabolic pathway involving the synthesis of a glutamate pool as precursor to aspartate and GABA. Of the inhibitory transmitter amino acids, GABA concentrations routinely exceeded those of glycine, but glycine concentrations were relatively high in brainstem auditory structures. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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