Phospholipid metabolism in bile duct-ligated rat plasma and erythrocytes
| Autor: | Ishikawa Hideto, Sakagami Toshio, Taniguchi Masako |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Male
medicine.medical_specialty Erythrocytes Time Factors medicine.drug_class Biophysics Phospholipid Biology Biochemistry Phosphates Bile Acids and Salts chemistry.chemical_compound Endocrinology In vivo Phosphatidylcholine Internal medicine medicine Animals Phospholipids Bile acid Bile duct Lysophosphatidylcholines Rats Inbred Strains Rats Red blood cell Lysophosphatidylcholine medicine.anatomical_structure Liver chemistry Biliary tract Bile Ducts |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 876:631-638 |
| ISSN: | 0005-2760 |
| DOI: | 10.1016/0005-2760(86)90052-4 |
| Popis: | Incorporation of [32P]orthophosphate into phosphatidylcholine, lysophosphatidylcholine and molecular species of phosphatidylcholine in vivo was observed in liver, plasma and erythrocytes of bile duct-ligated or sham-operated rats. Both the amount and radioactivity of dienoic species of phosphatidylcholine in all tissues examined increased in bile duct-ligated rats as compared to sham-operated rats. The experiments in vivo and in vitro showed that the ratio of lysophosphatidylcholine to phosphatidylcholine transferred to erythrocytes from plasma in sham-operated rats was much higher than that in bile duct-ligated rats. It is suggested that one of the mechanisms by which abnormal erythrocytes appear might be explained by the facilitated and direct transfer of phosphatidylcholine, which is caused by the interaction of erythrocytes with bile acid in bile duct-ligated rat plasma. |
| Databáze: | OpenAIRE |
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