| Autor: |
Erik R. Hebels, Felix Bindt, Johanna Walther, Michiel van Geijn, Jimmy Weterings, Qizhi Hu, Claudio Colombo, Rob Liskamp, Cristianne Rijcken, Wim E. Hennink, Tina Vermonden |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Biomacromolecules. |
| ISSN: |
1526-4602 |
| Popis: |
Polymeric micelles (PMs) are promising platforms for enhanced tissue targeting of entrapped therapeutic agents. Strategies to circumvent premature release of entrapped drugs include cross-linking of the micellar core as well as covalent attachment of the drug cargo. The chemistry employed to obtain cross-linked micelles needs to be mild to also allow entrapment of fragile molecules, such as certain peptides, proteins, oligonucleotides, and fluorescent dyes. Native chemical ligation (NCL) is a mild bio-orthogonal reaction between a |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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