Repeated social defeat in female pigs does not induce neuroendocrine symptoms of depression, but behavioral adaptation

Autor: van der Stalay, F. J., de Groot, J., Schuunnan, T., Korte, S. M., Sub BasicPharmacology&Psychopharmacology
Přispěvatelé: Sub BasicPharmacology&Psychopharmacology
Jazyk: angličtina
Rok vydání: 2008
Předmět:
SALIVARY CORTISOL
Time Factors
Hydrocortisone
Swine
Hippocampus
UNACQUAINTED PIGS
Behavioral neuroscience
GROWING GILTS
Social defeat
Behavioral Neuroscience
POSTTRAUMATIC-STRESS-DISORDER
FAMILIARITY
Adaptation
Psychological
glucocorticoid receptor
PIGLETS
Behavior
Animal
social stress
MEDULLARY SEROTONERGIC SYSTEM
serotonin
ANIMAL-MODELS
depression
Female
medicine.symptom
Psychology
Glucocorticoid
Wageningen Livestock Research
medicine.drug
Dominance-Subordination
medicine.medical_specialty
Experimental and Cognitive Psychology
cortisol
Receptors
Glucocorticoid
Internal medicine
Animal models of depression
Physiology (medical)
medicine
Animals
CONFRONTATION
Saliva
mineralocorticoid receptor
Social stress
CONSEQUENCES
Aggression
HPA axis
animal model
Receptors
Mineralocorticoid
Endocrinology
Gene Expression Regulation
ID - Dier en Omgeving
Zdroj: Physiology & behavior, 93(3), 453. Elsevier
Physiology and Behavior, 93(3), 453-460
Physiology and Behavior 93 (2008) 3
ISSN: 0031-9384
Popis: The aim of this study was to develop an animal model of major depression. Since two thirds of depressive patients are women, it is important to develop specific female animal models of depression. We therefore determined the consequences of chronic social defeat in individually housed prepubertal female pigs confronted with a dominant, older pig. Repeated defeat increased the salivary cortisol level, measured immediately after the confrontations, but this effect diminished after repeated confrontations. Neither organ weights nor the number of glucocorticoid (GR) and mineralocorticoid (MR) receptors in the ventral hippocampus were affected by repeated defeat. Scrotonin turnover in the dorsal hippocarnpus was also unaffected. Behavioral analysis revealed that across confrontations, the pigs reduced the time spent actively attacking the dominant pigs, whereas the time increased in which the pigs passively underwent aggression and/or actively avoided aggression. Therefore, we conclude that the repeated social defeat paradigm does not induce long-lasting depression-like neuroendocrine effects as a consequence of behavioral adaptations (changes in the fighting strategy) in the young female pigs. (C) 2007 Elsevier Inc. All rights reserved.
Databáze: OpenAIRE
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