Graphene quantum dots with nitrogen-doped content dependence for highly efficient dual-modality photodynamic antimicrobial therapy and bioimaging
| Autor: | Shean-Jen Chen, Yu Ting Shao, Hua Han Chen, Jiu Yao Wang, Shih Yao Chen, Wen Shuo Kuo, Pei Chi Chen, Yung I. Hou, Shang Rung Wu, Chih Li Lilian Hsu, Yi-Chun Chen, Chia Yuan Chang, Hui Fang Kao |
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| Rok vydání: | 2016 |
| Předmět: |
Materials science
Nitrogen medicine.medical_treatment Biophysics Bioengineering Nanotechnology Photodynamic therapy 02 engineering and technology 010402 general chemistry 01 natural sciences Theranostic Nanomedicine law.invention Biomaterials Anti-Infective Agents law Quantum Dots medicine Escherichia coli Photosensitizer Photosensitizing Agents Graphene technology industry and agriculture 021001 nanoscience & nanotechnology Antimicrobial Graphene quantum dot 0104 chemical sciences Microscopy Fluorescence Photochemotherapy Mechanics of Materials Quantum dot Cell Tracking Luminescent Measurements Ceramics and Composites Dual modality Graphite 0210 nano-technology Luminescence |
| Zdroj: | Biomaterials. 120 |
| ISSN: | 1878-5905 |
| Popis: | Reactive oxygen species is the main contributor to photodynamic therapy. The results of this study show that a nitrogen-doped graphene quantum dot, serving as a photosensitizer, was capable of generating a higher amount of reactive oxygen species than a nitrogen-free graphene quantum dot in photodynamic therapy when photoexcited for only 3 min of 670 nm laser exposure (0.1 W cm-2), indicating highly improved antimicrobial effects. In addition, we found that higher nitrogen-bonding compositions of graphene quantum dots more efficiently performed photodynamic therapy actions than did the lower compositions that underwent identical treatments. Furthermore, the intrinsically emitted luminescence from nitrogen-doped graphene quantum dots and high photostability simultaneously enabled it to act as a promising contrast probe for tracking and localizing bacteria in biomedical imaging. Thus, the dual modality of nitrogen-doped graphene quantum dots presents possibilities for future clinical applications, and in particular multidrug resistant bacteria. |
| Databáze: | OpenAIRE |
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