Intestinal Expression of ACE2 in Mice with High-Fat Diet-Induced Obesity and Neonates Exposed to Maternal High-Fat Diet
| Autor: | Jia Sun, Luo Chen, Xiao-Ao Xiao, Yuanqing Gao, Han Jiao, Xin-Yuan Wang, Mo-Qiu Jia |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Offspring Macrophage Endocrinology Diabetes and Metabolism Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ACE2 030209 endocrinology & metabolism Disease Peptidyl-Dipeptidase A Diet High-Fat Article 03 medical and health sciences Mice 0302 clinical medicine Internal medicine medicine Animals Humans Obesity Receptor chemistry.chemical_classification 030109 nutrition & dietetics Nutrition and Dietetics business.industry SARS-CoV-2 nutritional and metabolic diseases COVID-19 High fat diet medicine.disease Intestine Intestines Enzyme Endocrinology High-fat diet chemistry Angiotensin-Converting Enzyme 2 business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Nutrition (Burbank, Los Angeles County, Calif.) |
| ISSN: | 1873-1244 0899-9007 |
| Popis: | Objective The 2019 novel coronavirus disease (COVID-19) is threatening global health and is especially pronounced in patients with chronic metabolic syndromes. Meanwhile, a significant proportion of patients present with digestive symptoms since angiotensin-converting enzyme 2 (ACE2), which is the receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is highly expressed in the intestine. The aim of this study was to evaluate the effects of a high-fat diet (HFD) and a maternal HFD on the intestinal ACE2 levels in adults and neonates. Methods We examined intestinal ACE2 protein levels in mice with diet-induced obesity (DIO) and neonatal mice exposed to a maternal HFD. We also investigated Ace2 mRNA expression in intestinal macrophages. Results Intestinal ACE2 protein levels were increased in DIO mice but decreased in offspring exposed to a maternal HFD compared with chow-fed controls. Ace2 mRNA expression in intestinal macrophages was detected and downregulated in DIO mice. Additionally, higher intestinal ACE2 protein levels were observed in neonates than in adult mice. Conclusions The influence of an HFD on intestinal ACE2 protein levels is opposite in adults and neonates. Macrophages might also be involved in SARS-CoV-2 intestinal infection. These findings provide some clues for the outcomes of patients with COVID-19 with metabolic syndromes. |
| Databáze: | OpenAIRE |
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