Joint effect of asthma/atopy and an IL-6 gene polymorphism on lung cancer risk among lifetime non-smoking Chinese women
| Autor: | Daniel P. K. Ng, Philip Eng, Wee-Teng Poh, Teh Ming, Yee-Tang Wang, Adeline Seow, Serena Choo |
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| Rok vydání: | 2005 |
| Předmět: |
Hypersensitivity
Immediate China Cancer Research Allergy Lung Neoplasms Atopy Odds Ratio medicine Humans Genetic Predisposition to Disease Lung cancer Aged Asthma Inflammation Polymorphism Genetic Interleukin-6 business.industry Smoking Cancer General Medicine Odds ratio Atopic dermatitis Middle Aged medicine.disease respiratory tract diseases Case-Control Studies Immunology Female Gene polymorphism business |
| Zdroj: | Carcinogenesis. 27:1240-1244 |
| ISSN: | 1460-2180 0143-3334 |
| DOI: | 10.1093/carcin/bgi309 |
| Popis: | Recent evidence suggests that inflammatory pathways are important mediators of carcinogenesis. Asthma, allergic rhinitis and atopic dermatitis are clinical manifestations of a systemic atopic disorder, which is associated with airway hyper-responsiveness and inflammation. We examined the effect of a history of asthma/atopy among 132 lung cancer cases (of which 72% were adenocarcinomas) and 163 controls, all of whom were non-smoking Chinese women, in combination with a single nucleotide polymorphism (-634C/G) in the interleukin-6 (IL-6) gene which regulates secretion of a pro-inflammatory cytokine found to be predominant in lung tumour tissue. We observed a slight increase in risk of lung cancer [odds ratio, OR = 1.5, 95% confidence interval (95% CI) = 0.8-2.6] and of adenocarcinoma (OR = 1.6, 95% CI = 0.9-3.1) with asthma/ atopy alone. There was no effect of the IL-6 CG/GG genotype on lung cancer risk on its own. Among individuals with both asthma/atopy and the IL-6 -634 G allele, however, risk was increased at least 3-fold (OR = 3.1, 95% CI = 1.2-8.3 for all cancers and OR = 4.2, 95% CI = 1.5-11.6 for adenocarcinomas) relative to individuals with no asthma/atopy and the CC genotype. On stratified analysis, a significant increase in risk with asthma/atopy was restricted to those with the at-risk genotype (Pint < 0.05). Our findings are consistent with the role of chronic inflammation as an aetiologic factor among non-smoking Asian women, and suggest that asthma/atopy is a risk marker for susceptibility to the development of lung cancer. |
| Databáze: | OpenAIRE |
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