CXCL12 G801A polymorphism and susceptibility to glioma: a case‑control study
| Autor: | S.L. Li, B. Yang, S.F. Chang, R.H. Miao, K.M. Zhang, G.F. Liang, K.M. Yao |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Oncology
Male medicine.medical_specialty Genotype Biology CXCR4 Polymorphism Single Nucleotide Metastasis Asian People Risk Factors Glioma Internal medicine Genetics medicine Humans Genetic Predisposition to Disease neoplasms Molecular Biology Genetic Association Studies Case-control study Histology General Medicine medicine.disease biological factors Chemokine CXCL12 nervous system diseases Case-Control Studies embryonic structures Immunology Female biological phenomena cell phenomena and immunity Neoplasm Grading Who classification Stage iv |
| Zdroj: | Genetics and molecular research : GMR. 14(4) |
| ISSN: | 1676-5680 |
| Popis: | Previous studies have demonstrated that the CXCL12 G801A polymorphism is closely correlated with tumor susceptibility. In addition, the CXCL12/CXCR4 pathway is closely related to proliferation, metastasis, and invasion of glioma. However, the genetic effects of the CXCL12 G801A polymorphism on glioma risk in Chinese populations remain unknown. In this study, we investigated the potential associations between the CXCL12 G801A polymorphism with glioma susceptibility and its clinicopathological characteristics. Frequencies of CXCL12 G801A polymorphic variants between glioma patients (N = 750) and healthy controls (N = 750) were assessed using restriction length fragment polymorphism analysis. The association among the CXCL12 G801A polymorphism, glioma grade (WHO classification), and histological type was also evaluated. Our results showed that patients with glioma had significantly higher frequency of the CXCL12-3' A/A genotypes (P = 0.039) as compared with healthy controls. When stratified by the glioma histology, high-grade glioma patients had significantly higher frequency of the CXCL12-3' A/A genotypes (P = 0.019) as compared with low-grade glioma patients. When stratified by the WHO grade, significantly higher frequency of the CXCL12-3' A/A genotype was observed in stage IV glioma patients (P = 0.037). We conclude that the CXCL12 G801A polymorphism is a risk factor that increases susceptibility to gliomas in a subset of the general Han Chinese population. |
| Databáze: | OpenAIRE |
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