Thyroid Hormones and Cardiovascular Function and Diseases
| Autor: | Irwin Klein, Giorgio Iervasi, Robin P. Peeters, Alessandro Pingitore, Salman Razvi, Bernadette Biondi, Azfar Zaman, Avais Jabbar, Sara Danzi |
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| Přispěvatelé: | Internal Medicine, Razvi, Salman, Jabbar, Avai, Pingitore, Alessandro, Danzi, Sara, Biondi, Bernadette, Klein, Irwin, Peeters, Robin, Zaman, Azfar, Iervasi, Giorgio |
| Rok vydání: | 2018 |
| Předmět: |
Thyroid Hormones
medicine.medical_specialty Heart Diseases 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Hyperthyroidism 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine medicine Humans Myocardial infarction Endothelial dysfunction Triiodothyronine business.industry Thyroid medicine.disease Blood pressure medicine.anatomical_structure Heart failure Cardiology Cardiovascular risk thyroid dysfucntion heart failure subclinical thyroid disease Cardiology and Cardiovascular Medicine business Dyslipidemia Hormone |
| Zdroj: | Journal of the American College of Cardiology, 71(16), 1781-1796. Elsevier Inc. |
| ISSN: | 0735-1097 |
| DOI: | 10.1016/j.jacc.2018.02.045 |
| Popis: | Thyroid hormone (TH) receptors are present in the myocardium and vascular tissue, and minor alterations in TH concentration can affect cardiovascular (CV) physiology. The potential mechanisms that link CV disease with thyroid dysfunction are endothelial dysfunction, changes in blood pressure, myocardial systolic and diastolic dysfunction, and dyslipidemia. In addition, cardiac disease itself may lead to alterations in TH concentrations (notably, low triiodothyronine syndrome) that are associated with higher morbidity and mortality. Experimental data and small clinical trials have suggested a beneficial role of TH in ameliorating CV disease. The aim of this review is to provide clinicians dealing with CV conditions with an overview of the current knowledge of TH perturbations in CV disease. |
| Databáze: | OpenAIRE |
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