Randomised controlled trial of adjunctive inspiratory muscle training for patients with COPD
| Autor: | Eric Derom, Tessa Schneeberger, François Maltais, Rik Gosselink, Stefanie Vermeersch, Daniel Langer, Yvonne F. Heijdra, Heleen Demeyer, Marc Decramer, Rainer Gloeckl, Alison K. McConnell, Linda Garms, Hanneke van Helvoort, Noppawan Charususin, Klaus Kenn, Didier Saey |
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| Rok vydání: | 2018 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male Weakness medicine.medical_specialty medicine.medical_treatment Walk Test Breathing Exercises Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18] law.invention 03 medical and health sciences Pulmonary Disease Chronic Obstructive 0302 clinical medicine Randomized controlled trial Double-Blind Method law Respiratory muscle Medicine Humans Pulmonary rehabilitation 030212 general & internal medicine Respiratory system Aged COPD Rehabilitation business.industry Inspiratory muscle training Middle Aged medicine.disease Respiratory Muscles 030228 respiratory system Inflammatory diseases Radboud Institute for Health Sciences [Radboudumc 5] Physical therapy Physical Endurance Female medicine.symptom business |
| Zdroj: | Thorax, 73, 10, pp. 942-950 Thorax, 73, 942-950 |
| ISSN: | 0040-6376 |
| DOI: | 10.1136/thoraxjnl-2017-211417 |
| Popis: | BackgroundThis study aimed to investigate whether adjunctive inspiratory muscle training (IMT) can enhance the well-established benefits of pulmonary rehabilitation (PR) in patients with COPD.Methods219 patients with COPD (FEV1: 42%±16% predicted) with inspiratory muscle weakness (PImax: 51±15 cm H2O) were randomised into an intervention group (IMT+PR; n=110) or a control group (Sham-IMT+PR; n=109) in this double-blind, multicentre randomised controlled trial between February 2012 and October 2016 (ClinicalTrials.govNCT01397396). Improvement in 6 min walking distance (6MWD) was a priori defined as the primary outcome. Prespecified secondary outcomes included respiratory muscle function and endurance cycling time.FindingsNo significant differences between the intervention group (n=89) and the control group (n=85) in improvements in 6MWD were observed (0.3 m, 95% CI −13 to 14, p=0.967). Patients who completed assessments in the intervention group achieved larger gains in inspiratory muscle strength (effect size: 1.07, pInterpretationImprovements in respiratory muscle function after adjunctive IMT did not translate into additional improvements in 6MWD (primary outcome). Additional gains in endurance time and reductions in symptoms of dyspnoea were observed during an endurance cycling test (secondary outcome)Trial registration numberNCT01397396; Results. |
| Databáze: | OpenAIRE |
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