Role of CR4 in Mycobacterium tuberculosis-human macrophages binding and signal transduction in the absence of serum
| Autor: | Jerrold J. Ellner, Yona Zaffran, Li Zhang |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Phagocytosis
Immunology Integrin alphaXbeta2 chemical and pharmacologic phenomena CHO Cells Biology Microbiology Mycobacterium tuberculosis chemistry.chemical_compound Cricetinae Macrophage Animals Humans Phosphorylation Opsonin Cells Cultured Binding protein Macrophages Tyrosine phosphorylation biology.organism_classification Infectious Diseases chemistry Molecular and Cellular Pathogenesis Parasitology Signal transduction Signal Transduction |
| Zdroj: | Infection and immunity. 66(9) |
| ISSN: | 0019-9567 |
| Popis: | The β2 integrin CR4 is involved in Mycobacterium tuberculosis phagocytosis by human mononuclear phagocytes through the opsonin C3bi. In this study, we demonstrate that M. tuberculosis can bind directly to monocyte-derived macrophages via CR4 in the absence of any opsonins. CR4-transfected CHO cells gave similar results, suggesting recognition by CR4 of bacterial structure. Furthermore, binding of M. tuberculosis transduced a potent signal, resulting in tyrosine phosphorylation of macrophage proteins, which was in part mediated by CR4. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|