Cross-sectional analysis of glucose metabolism in Friedreich Ataxia
| Autor: | Nathaniel R. Greeley, David A. Lynch, Sean R. Regner, Steve Willi |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Ataxia Adolescent medicine.medical_treatment Carbohydrate metabolism Models Biological Body Mass Index Young Adult Sex Factors Insulin resistance Iron-Binding Proteins Diabetes mellitus Internal medicine Diabetes Mellitus medicine Homeostasis Humans Insulin Point Mutation Child Aged Glycated Hemoglobin Genetics biology Age Factors nutritional and metabolic diseases Fasting Middle Aged medicine.disease Cross-Sectional Studies Endocrinology Neurology Friedreich Ataxia Child Preschool Homeostatic model assessment Frataxin biology.protein Female Neurology (clinical) medicine.symptom Trinucleotide Repeat Expansion Body mass index |
| Zdroj: | Journal of the Neurological Sciences. 342:29-35 |
| ISSN: | 0022-510X |
| DOI: | 10.1016/j.jns.2014.04.015 |
| Popis: | Objectives To evaluate the relationship between disease features in Friedreich ataxia and aberrant glucose metabolism. Methods Fasting glucose, fasting insulin and random HbA1C were obtained in 158 patients with Friedreich ataxia. Regression analysis evaluated glucose, insulin, and homeostatic model assessment (HOMA) of insulin resistance (IR) and beta-cell function (s) in relation to age, BMI, sex, and genetic severity. Categorical glucose values were analyzed in relation to other FRDA-associated disease characteristics. Results In the FRDA cohort, age and GAA repeat length predicted fasting glucose and HbA1c levels (accounting for sex and BMI), while insulin and HOMA-IR were not predicted by these parameters. Within the cohort, average BMI was consistently lower than the national average by age and was marginally associated with insulin levels and HOMA-IR. Within juvenile subjects, insulin and HOMA-IR were predicted by age. Controlling for age and genetic severity, diabetes-related measures were not independent predictors of any quantitative measure of disease severity in FRDA. Glucose handling properties were also predicted by the presence of a point mutation, with 40% of individuals heterozygous for point mutations having diabetes, compared to 4.3% of subjects who carried two expanded GAA repeats. Interpretation In FRDA, aberrant glucose metabolism is linked to increasing age, longer GAA repeat length on the shorter allele, frataxin point mutations, and increasing BMI. The effect of age to some degree may be mediated through changes in BMI, with increasing age associated with increases in BMI, and with HOMA-IR and insulin increases in children. |
| Databáze: | OpenAIRE |
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