Role of the GATA family of transcription factors in endocrine development, function, and disease
| Autor: | Mikko Anttonen, Markku Heikinheimo, Séverine Mazaud Guittot, David B. Wilson, Robert S. Viger |
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| Přispěvatelé: | Communications Cellulaires et Différenciation (CCD), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), Children's Hospital |
| Rok vydání: | 2008 |
| Předmět: |
MESH: Protein Isoforms/physiology
Transcription Genetic MESH: GATA Transcription Factors/metabolism Endocrine System Biology Endocrine System Diseases GATA Transcription Factors Models Biological 03 medical and health sciences 0302 clinical medicine Endocrinology MESH: Endocrine System/growth & development Animals Humans Protein Isoforms MESH: Animals Molecular Biology Gene Transcription factor 030304 developmental biology MESH: GATA Transcription Factors/genetics Genetics 0303 health sciences Gene knockdown GATA6 MESH: Protein Isoforms/genetics MESH: Humans MESH: Transcription Genetic GATA2 MESH: Endocrine System/metabolism MESH: Models Biological GATA1 MESH: GATA Transcription Factors/physiology General Medicine MESH: Endocrine System Diseases/metabolism [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism MESH: Endocrine System Diseases/pathology Regulatory sequence 030220 oncology & carcinogenesis GATA transcription factor Minireview MESH: Protein Isoforms/metabolism |
| Zdroj: | Molecular Endocrinology-Baltimore Molecular Endocrinology-Baltimore-, Endocrine Society, 2008, 22 (4), pp. 781-98. ⟨10.1210/me.2007-0513⟩ |
| ISSN: | 0888-8809 |
| DOI: | 10.1210/me.2007-0513⟩ |
| Popis: | International audience; The WGATAR motif is a common nucleotide sequence found in the transcriptional regulatory regions of numerous genes. In vertebrates, these motifs are bound by one of six factors (GATA1 to GATA6) that constitute the GATA family of transcriptional regulatory proteins. Although originally considered for their roles in hematopoietic cells and the heart, GATA factors are now known to be expressed in a wide variety of tissues where they act as critical regulators of cell-specific gene expression. This includes multiple endocrine organs such as the pituitary, pancreas, adrenals, and especially the gonads. Insights into the functional roles played by GATA factors in adult organ systems have been hampered by the early embryonic lethality associated with the different Gata-null mice. This is now being overcome with the generation of tissue-specific knockout models and other knockdown strategies. These approaches, together with the increasing number of human GATA-related pathologies have greatly broadened the scope of GATA-dependent genes and, importantly, have shown that GATA action is not necessarily limited to early development. This has been particularly evident in endocrine organs where GATA factors appear to contribute to the transcription of multiple hormone-encoding genes. This review provides an overview of the GATA family of transcription factors as they relate to endocrine function and disease. |
| Databáze: | OpenAIRE |
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