Pure white cell aplasia: report of first case associated with autoimmune hepatitis

Autor:	Thomas Keast, Stamford Mathe, Richard Grace, Phil Mayhead, Deshan Weeraman
Rok vydání:	2014
Předmět:	Hepatology medicine.diagnostic_test business.industry medicine.medical_treatment Gastroenterology Autoantibody Immunosuppression Aplasia Autoimmune hepatitis Jaundice medicine.disease Liver Liver biopsy Immunology Medicine Myelopoiesis medicine.symptom business Adverse drug reaction
Zdroj:	Frontline Gastroenterology. 5:287-290
ISSN:	2041-4145 2041-4137
DOI:	10.1136/flgastro-2013-100427
Popis:	Pure white cell aplasia (PWCA) is a rare, immune-mediated condition that causes a profound inhibition of myelopoiesis. It has been seen in association with other autoimmune conditions, thymomas, chronic lymphocytic leukaemia and as an adverse drug reaction. We report what we believe to be the first case of PWCA associated with autoimmune hepatitis. An 18-year-old woman presented with jaundice and was found to be suffering from acute hepatitis. Later she became neutropenic and lymphopenic. Liver biopsy was indicative of autoimmune hepatitis. This was later confirmed by autoantibody results. Bone marrow aspirate found an absence of all myeloid progenitor cells, highly suggestive of PWCA. The low white cell count only improved after immunosuppression with corticosteroids. Her condition remains stable 1 year later with azathioprine therapy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96b9740e1177a7d19d3ecfef3d784490 https://doi.org/10.1136/flgastro-2013-100427 Zobrazit plný text záznamu