Neurophysiology of Arthritis Pain
| Autor: | Jason J. McDougall, Patrick Linton |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Pain medicine
Receptors Proteinase-Activated Neurophysiology Pain Arthritis Osteoarthritis Sodium Channels Transient receptor potential channel Transient Receptor Potential Channels Sodium channel blocker medicine Humans business.industry Peripheral Nervous System Diseases General Medicine medicine.disease Anesthesiology and Pain Medicine Joint pain Anesthesia Cytokines Neurology (clinical) Arthritis pain medicine.symptom business Neuroscience Endocannabinoids |
| Zdroj: | Current Pain and Headache Reports. 16:485-491 |
| ISSN: | 1534-3081 1531-3433 |
| DOI: | 10.1007/s11916-012-0300-0 |
| Popis: | Arthritis pain is a complex phenomenon involving intricate neurophysiological processing at all levels of the pain pathway. The treatment options available to alleviate joint pain are fairly limited and most arthritis patients report only modest pain relief with current treatments. A better understanding of the neural mechanisms responsible for musculoskeletal pain and the identification of new targets will help in the development of future pharmacological therapies. This article reviews some of the latest research into factors which contribute to joint pain and covers areas such as cannabinoids, proteinase activated receptors, sodium channels, cytokines and transient receptor potential channels. The emerging hypothesis that osteoarthritis may have a neuropathic component is also discussed. |
| Databáze: | OpenAIRE |
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