Long-term survival in a dog with anaplastic oligodendroglioma treated with radiation therapy and CCNU
| Autor: | Michio Fujita, Daisuke Hasegawa, Takayuki Kuwabara, Shunta Mizoguchi, Kazuyuki Uchida, Naoko Yayoshi |
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| Rok vydání: | 2012 |
| Předmět: |
Involution (mathematics)
Male medicine.medical_specialty Hypofractionated Radiation Therapy medicine.medical_treatment biology.animal_breed Oligodendroglioma Status epilepticus French bulldog Lesion Dogs Fatal Outcome Status Epilepticus Lomustine Glioma medicine Animals Dog Diseases Chemotherapy General Veterinary biology business.industry medicine.disease Immunohistochemistry Magnetic Resonance Imaging Surgery Radiation therapy medicine.symptom Neoplasm Recurrence Local Particle Accelerators business |
| Zdroj: | The Journal of veterinary medical science. 74(11) |
| ISSN: | 1347-7439 |
| Popis: | A 9 year-old, neutered, male French Bulldog showing cluster seizures was diagnosed with a glioma in the right piriform cortex by MRI. Hypofractionated radiation therapy (RT) was performed using a linear accelerator. Although the lesion had involuted significantly at 2 months after RT, recurrence was observed at 4 months after RT. Chemotherapy was started using CCNU (60 mg/m(2) every 6-9 weeks) and was continued for one year. Follow-up MRI revealed involution of the lesion and the intervals of CCNU were increased to every 9-14 weeks. Two years after the first presentation, the dog suffered status epilepticus, followed by deficits of left sided postural reaction with cognitive dysfunction. The dog died on day 910, and histopathological diagnosis confirmed anaplastic oligodendroglioma. |
| Databáze: | OpenAIRE |
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