Influence of palliative surgical resection on overall survival in patients with advanced colorectal cancer: a retrospective single institutional study

Autor: Bhoomi Mehrotra, Neetu Radhakrishnan, Matthew Kaufman, G. Gecelter, S. Nissel-Horowitz, James Tsang, R. Roy, A. Thomas
Rok vydání: 2008
Předmět:
Zdroj: Colorectal Disease. 10:498-502
ISSN: 1463-1318
1462-8910
DOI: 10.1111/j.1463-1318.2007.01384.x
Popis: Background The role of palliative surgical resection in patients presenting with locally advanced or metastatic colorectal cancer (CRC) is unclear. Resection is often limited to symptomatic management of bleeding, obstruction, perforation or for relief of pain, in patients with an adequate performance status and an expected life span of over several weeks. An exploratory analysis to evaluate the influence of a palliative surgical resection on survival outcome in patients with advanced CRC is reported. Method A retrospective review of medical records of all patients diagnosed with advanced CRC at our institution between the years 1998 and 2003 was undertaken. Tumour registry data were reviewed to identify age, gender, modalities of therapy [i.e. surgery (S), chemotherapy (C), radiation] and overall survival. IRB approval was obtained for this study. Results One hundred and eighty-five patients were identified. Median age was 67 years (range 30–99). M:F ratio was 1:1. Sixty-two per cent of patients (115/185) underwent a palliative surgical intervention. Median survival of patients who underwent S and those that did not undergo S was 22 and 3 months respectively (P
Databáze: OpenAIRE
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