Paclitaxel and spirulina co-loaded polymeric nanoparticles: in-vitro and in-vivo anticancer study
| Autor: | Keerthi G. S. Nair, Akshya Sekar, Yamuna Ravikumar, Ramaiyan Velmurugan, Dorcas Pinky Catherine |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Spirulina (genus)
biology Paclitaxel Nanoparticle Cancer Pharmacology Anticancer mechanism biology.organism_classification Polymeric nanoparticles medicine.disease In vitro RS1-441 chemistry.chemical_compound In-vitro Pharmacy and materia medica chemistry In vivo In-vivo medicine Spirulina Gastric cancer |
| Zdroj: | Brazilian Journal of Pharmaceutical Sciences, Vol 56 (2021) Brazilian Journal of Pharmaceutical Sciences, Volume: 56, Article number: e18996, Published: 26 APR 2021 |
| ISSN: | 2175-9790 |
| Popis: | Paclitaxel spirulina nanoparticles were said to have promising anticancer activity against gastric cancer. Nanoparticles of paclitaxel-spirulina were prepared for treating gastric cancer using precipitation technique. The synergistic anticancer efficiency againstMKN45 cells retains when the paclitaxel and spirulina were encapsulated into nanoparticles. To increase the site specific delivery, intra-tumoral administration was carried in the in vivo evaluation. There was an increase in overall survival in an MKN45-transplanted mice model and notable improvement in anti-tumour efficacy when paclitaxel-spirulina nanoparticles were delivered through intra-tumoral administration. The further investigation of overall anticancer mechanism of these nanoparticles is made as a major part in this research. Hence, the conjecture of this research is that, the paclitaxel-spirulina encapsulated nanoparticles could be an effective chemotherapeutic formulation for gastric cancer. |
| Databáze: | OpenAIRE |
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