The effect of topiramate and lamotrigine on rat bone mass, structure and metabolism
| Autor: | Helena Zivna, Vladimir Palicka, Martin Vališ, Iveta Gradosova, Jana Malakova, Sona Fekete, Pavel Zivny, Julius Simko |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Topiramate medicine.medical_specialty Administration Oral Bone Morphogenetic Protein 2 Enzyme-Linked Immunosorbent Assay Fructose Lamotrigine Bone and Bones Collagen Type I Statistics Nonparametric Bone remodeling Absorptiometry Photon Bone Density Internal medicine medicine Animals Femur Rats Wistar Bone mineral Triazines business.industry Body Weight Bone markers Osteoprotegerin Metabolism Alkaline Phosphatase Peptide Fragments Biomechanical Phenomena Rats Endocrinology Neurology Models Animal Body Composition Anticonvulsants Neurology (clinical) Peptides business Orchiectomy Procollagen medicine.drug Bone mass |
| Zdroj: | Journal of the Neurological Sciences. 340:80-85 |
| ISSN: | 0022-510X |
| DOI: | 10.1016/j.jns.2014.02.032 |
| Popis: | There is only limited data concerning the effect of the newer antiepileptic drugs on bone. The objective of this study was to determine the effect of topiramate (TPM) and lamotrigine (LTG) monotherapy on bone mineral density (BMD), mineral content (BMC), bone markers, body composition and bone mechanical strength in the orchidectomized (ORX) rat model. 24 orchidectomized Wistar rats were divided into control and test groups, 8 rats in each group. The control rats received standard laboratory diet (SLD) while rats in the test group were fed with SLD enriched with LTG or TPM for 12 weeks. Dual energy X-ray absorptiometry was used to measure bone mineral density. The concentrations of bone metabolism markers were assayed in bone homogenate. In addition, both femurs were measured and used for biomechanical testing. Compared to the control group, both test groups had significantly lower weight, fat mass, whole body and femur BMD, BMC and reduced mechanical strength of bone. All of these changes were more pronounced in rats exposed to LTG. In conclusion, both LTG and TPM significantly reduce BMD and body weight and impair mechanical strength of bone. A question arises as to the degree of dependence of the effect on the dose. Further studies are warranted to establish whether LTG and TPM may have a clinically significant effect on BMD exclusively in the model of gonadectomized rats, or whether the effect applies also in the model of gonadally intact animals, and in the respective human models. |
| Databáze: | OpenAIRE |
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