Alternative Energy: Breaking Down the Diverse Metabolic Features of Lung Cancers
| Autor: | Kasey R. Cargill, William L. Hasken, Carl M. Gay, Lauren A. Byers |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
glycolysis (Warburg effect) Lung business.industry Metabolic reprogramming oxidative phosphorylation Cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens Treatment of lung cancer Review medicine.disease Bioinformatics Warburg effect lung cancer metabolic inhibitors medicine.anatomical_structure Oncology Cancer cell medicine business Lung cancer METABOLIC FEATURES metabolism RC254-282 |
| Zdroj: | Frontiers in Oncology Frontiers in Oncology, Vol 11 (2021) |
| ISSN: | 2234-943X |
| Popis: | Metabolic reprogramming is a hallmark of cancer initiation, progression, and relapse. From the initial observation that cancer cells preferentially ferment glucose to lactate, termed the Warburg effect, to emerging evidence indicating that metabolic heterogeneity and mitochondrial metabolism are also important for tumor growth, the complex mechanisms driving cancer metabolism remain vastly unknown. These unique shifts in metabolism must be further investigated in order to identify unique therapeutic targets for individuals afflicted by this aggressive disease. Although novel therapies have been developed to target metabolic vulnerabilities in a variety of cancer models, only limited efficacy has been achieved. In particular, lung cancer metabolism has remained relatively understudied and underutilized for the advancement of therapeutic strategies, however recent evidence suggests that lung cancers have unique metabolic preferences of their own. This review aims to provide an overview of essential metabolic mechanisms and potential therapeutic agents in order to increase evidence of targeted metabolic inhibition for the treatment of lung cancer, where novel therapeutics are desperately needed. |
| Databáze: | OpenAIRE |
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