Iodine-131 Therapy and Lacrimal Drainage System Toxicity: Nasal Localization Studies Using Whole Body Nuclear Scintigraphy and SPECT-CT
| Autor: | Achyut Ram Vyakaranam, Palkonda Vijay Anand Reddy, Mohammad Javed Ali, Giri Prasad, Jyotsna Eleshwarapu Rao |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Nose Single-photon emission computed tomography 030218 nuclear medicine & medical imaging Iodine Radioisotopes 03 medical and health sciences 0302 clinical medicine medicine Humans Thyroid Neoplasms Radionuclide Imaging Aged Retrospective Studies Tomography Emission-Computed Single-Photon Nasolacrimal duct medicine.diagnostic_test Whole-Body Scintigraphy business.industry Thyroid Dose-Response Relationship Radiation Retrospective cohort study General Medicine Middle Aged Nasal Mucosa Ophthalmology medicine.anatomical_structure Toxicity 030221 ophthalmology & optometry Female Surgery Nasal administration Nuclear medicine business |
| Zdroj: | Ophthalmic Plastic & Reconstructive Surgery. 33:13-16 |
| ISSN: | 0740-9303 |
| DOI: | 10.1097/iop.0000000000000603 |
| Popis: | Purpose The objective of this study was to evaluate the influence of dose on nasal localization of radioactive iodine-131 (I-131) following therapy for differentiated thyroid carcinomas. Methods Retrospective evaluation of all patients who underwent post-therapy I-131 whole body scintigraphy and single photon emission computed tomography was performed. Patients were divided into 2 groups; group A were treated with 100 millicurie (mCi) and group B with ≥150 mCi. Databases were reviewed for demographics, diagnosis, and administered dosage of I-131. Whole body scintigraphy images were retrieved and nasal uptake was analyzed and classified as nil to trace, low, moderate, and high uptake and corresponding single photon emission CTs were analyzed for radioactive nasal activity. Results A total of 100 patients were studied, 50 in each of the groups. The M:F ratio was 1.1:1 (27:23) in group A and 1.5:1 (30:20) in group B. The mean age was 43.12 years and 54.6 years in groups A and B, respectively. Papillary carcinoma of the thyroid was the most common type accounting for 82% (41/50) of patients in group A and 62% (31/50) in group B. Imaging studies revealed nil to trace nasal activity in 80% (40/50) in group A as compared with 56% (28/50) in group B. None of the patients in group A showed high nasal uptake, whereas 4% (2/50) in group B demonstrated such high activity. Conclusion Intranasal localization of radioactive I-131 was significant in patients receiving a dose of ≥150 mCi. Intranasal localization may partly explain toxicity to nasolacrimal duct and may be a risk factor for subsequent development of nasolacrimal duct obstructions. |
| Databáze: | OpenAIRE |
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