Dopaminergic regulation of granulocytopoiesis during cytostatic-induced myelosuppressions
| Autor: | Gol'dberg Ed, E. G. Skurikhin, A. M. Dygai, Minakova My, O. V. Pershina |
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| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Stromal cell medicine.drug_class Dopamine Biology Antimetabolite General Biochemistry Genetics and Molecular Biology Mice Precursor cell Internal medicine medicine Animals Cyclophosphamide geography geography.geographical_feature_category Regeneration (biology) Dopaminergic Brain General Medicine Myeloablative Agonists Cytostatic Agents Hematopoietic Stem Cells Islet Hematopoiesis Haematopoiesis Endocrinology Mice Inbred CBA Cancer research Dopamine Antagonists Haloperidol Female Fluorouracil Granulocytes medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 144:282-287 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | The role of the dopaminergic system in the regulation of the granulocytic hemopoietic stem was studied after administration of cyclophosphamide and 5-fluorouracil. Dopamine in the central nervous system promotes the development of cytostatic-induced myelosuppressions. The inhibitory effect of dopaminergic structures on granulocytopoiesis after administration the fluoropyrimidine antimetabolite was of shorter duration compared to that observed in experiments with the alkylating agent. The inhibitory effect of brain dopamine is associated with a decrease in proliferative activity and differentiation of granulomonocytic precursors, prevention of hemopoietic islet formation, and impairment of secretion of colony-stimulating activity in adherent cells of the hemopoiesis-inducing microenvironment. Cyclophosphamide and 5-fluorouracil had different effects on the rate of hemopoietic tissue regeneration, which was related to specific interaction between distant regulatory structures and hemopoiesis-inducing microenvironment and differences in the influence of cytostatics on hemopoietic and stromal cells. |
| Databáze: | OpenAIRE |
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