Relationship between renal function and blood level of chromogranin A
| Autor: | C. Annichiarico, M. Norpoth, Marco Ferdeghini, Claudio Bianchi, Romano Bianchi, Carlo Donadio, Gianfranco Tramonti |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Blood level
Adult Male endocrine system medicine.medical_specialty Adolescent Plasma creatinine Renal function urologic and male genital diseases Critical Care and Intensive Care Medicine Kidney Function Tests Internal medicine medicine Biomarkers Tumor Chromogranins Humans In patient Tumor-Associated Trypsin Inhibitor Aged beta(2) microglobulin chromogranin A glomerular filtration rate tumor associated with trypsin inhibitor tumor associated with trypsin inhibitor biology business.industry Beta-2 microglobulin Healthy subjects Chromogranin A General Medicine Middle Aged Endocrinology Nephrology Trypsin Inhibitor Kazal Pancreatic Creatinine biology.protein Female Kidney Diseases beta(2) microglobulin business beta 2-Microglobulin Glomerular Filtration Rate |
| Zdroj: | Renal failure. 23(3-4) |
| ISSN: | 0886-022X |
| Popis: | Chromogranin A (CGA) is a low MW (49,000) acidic hydrophilic protein. It is synthesized in the chromaffm granules of the neuroendocrine cells, and has been found circulating in the blood of healthy subjects. The aim of this study was to assess the relationship between serum levels of CGA and renal function. One hundred two renal patients (45 M and 57 F; age 14-76 years, mean 52) participated in the study. Glomerular filtration rate (GFR) was measured by the bladder cumulative method, using 99mTc-DTPA as a tracer. Blood CGA was determined by RIA. Plasma creatinine, beta2microglobulin (beta2m) and tumor associated trypsin inhibitor (TATI) were also determined. The reduction in renal function was associated with an increase in all of the above studied parameters. In patients with advanced renal failure (GFR20 mL/min) CGA levels increased by 22-fold as compared to the patients with normal renal function (GFR100 mL/min). The other studied parameters were also increased but to a lesser degree, e.g., TATI 14-, beta2m 8- and creatinine 5-fold. The results of this study demonstrate that renal handling of the CGA is similar to other low MW proteins, and it accumulates in the blood in renal failure. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|