Serotonin targets inhibitory synapses to induce modulation of network functions

Autor: Gerald Schlaf, Till Manzke, Uwe R. Koch, Michael Mörschel, Olivier Bidon, Evgeni Ponimaskin, Peter M. Lalley, Diethelm W. Richter, Mathias Dutschmann
Rok vydání: 2009
Předmět:
Periodicity
Serotonin
Pyridines
Nerve net
Pre-Bötzinger complex
Biology
Inhibitory postsynaptic potential
Efferent Pathways
Piperazines
General Biochemistry
Genetics and Molecular Biology
Membrane Potentials
Rats
Sprague-Dawley
03 medical and health sciences
0302 clinical medicine
Phenols
medicine
Animals
5-HT receptor
DNA Primers
030304 developmental biology
Calcium signaling
8-Hydroxy-2-(di-n-propylamino)tetralin
Sulfonamides
0303 health sciences
Reverse Transcriptase Polymerase Chain Reaction
Antibodies
Monoclonal
Long-term potentiation
Articles
Immunohistochemistry
Buspirone
Rats
Serotonin Receptor Agonists
medicine.anatomical_structure
Receptors
Serotonin
Synapses
Cats
Respiratory Mechanics
Excitatory postsynaptic potential
Nerve Net
General Agricultural and Biological Sciences
Neuroscience
030217 neurology & neurosurgery
Brain Stem
Zdroj: Philosophical Transactions of the Royal Society B: Biological Sciences. 364:2589-2602
ISSN: 1471-2970
0962-8436
Popis: The cellular effects of serotonin (5-HT), a neuromodulator with widespread influences in the central nervous system, have been investigated. Despite detailed knowledge about the molecular biology of cellular signalling, it is not possible to anticipate the responses of neuronal networks to a global action of 5-HT. Heterogeneous expression of various subtypes of serotonin receptors (5-HTR) in a variety of neurons differently equipped with cell-specific transmitter receptors and ion channel assemblies can provoke diverse cellular reactions resulting in various forms of network adjustment and, hence, motor behaviour.Using the respiratory network as a model for reciprocal synaptic inhibition, we demonstrate that 5-HT1AR modulation primarily affects inhibition through glycinergic synapses. Potentiation of glycinergic inhibition of both excitatory and inhibitory neurons induces a functional reorganization of the network leading to a characteristic change of motor output. The changes in network operation are robust and help to overcome opiate-induced respiratory depression. Hence, 5-HT1AR activation stabilizes the rhythmicity of breathing during opiate medication of pain.
Databáze: OpenAIRE
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