The roles of nutritional depletion and drug concentration in 5-fluorouracil-induced inhibition of colonic healing
| Autor: | Bengt Glimelius, Staffan Weiber, H. Jiborn, Lars Påhlman, Wilhelm Graf, Bengt Zederfeldt |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Normal diet Colon Anastomosis Gastroenterology Random Allocation Body Water Weight loss Reference Values Internal medicine medicine Animals Rats Wistar Wound Healing business.industry Anastomosis Surgical Body Weight Muscle Smooth Surgery Diet Rats Hydroxyproline Drug concentration Fluorouracil Toxicity Animal Nutritional Physiological Phenomena medicine.symptom Poor nutrition business medicine.drug Nutritional depletion |
| Zdroj: | The Journal of surgical research. 56(5) |
| ISSN: | 0022-4804 |
| Popis: | This study was performed to investigate whether poor nutrition is responsible for 5-fluorouracil (5-FU)-induced inhibition of large bowel healing and if the concentration of intraperitoneal (ip) 5-FU affects anastomotic healing. Male Wistar rats underwent a left colonic resection and were randomly assigned to a control group (n = 9, ip NaCl, normal diet), a nutritional depletion group (n = 12, ip NaCl, restricted diet), or a 5-FU group (n = 12, ip 5-FU, normal diet). Treatment was started immediately after surgery and continued until sacrifice after 7 days. Although the weight loss in the nutritional depletion group exceeded that in the 5-FU group, the anastomotic and skin breaking strength was lower in the latter group compared with that in the former group (P0.01 and P0.05, respectively). There were no significant differences in breaking strength between the nutritional depletion group and controls. A second series of male Wistar rats were similarly operated on and randomly assigned to a control group (n = 6, ip NaCl), a 5-FU high-concentration group (n = 10, (5 mg/ml ip 5-FU) or a 5-FU low-concentration group (n = 10, (1 mg/ml ip 5-FU). The 5-FU dose was the same in the two latter groups. The anastomotic breaking strength on Day 7 was reduced to a similar extent in the 5-FU groups (P0.01). These results indicate that the impaired anastomotic healing after ip 5-FU is not mainly due to nutritional factors or drug concentration. |
| Databáze: | OpenAIRE |
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