Alteration in lipid profile and lipid indices as cardiometabolic risk markers in psoriasis
| Autor: | Basavaraj Devaranavadagi, BalachandraS Ankad, Neela Mannangi, BB Mahantesh |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Cardiometabolic risk
medicine.medical_specialty medicine.diagnostic_test business.industry lcsh:RM1-950 General Medicine psoriasis medicine.disease lipid profile Endocrinology lcsh:Therapeutics. Pharmacology Psoriasis Internal medicine medicine lipids (amino acids peptides and proteins) aip business Lipid profile pasi score |
| Zdroj: | BLDE University Journal of Health Sciences, Vol 5, Iss 3, Pp 49-50 (2020) |
| ISSN: | 2456-1975 |
| Popis: | Background: Psoriasis is a chronic disorder characterized by erythematous scaly patches that affect the scalp, trunk, extensor surfaces of the limbs and the genital area. The high incidence of cardiovascular events in psoriasis is highly associated with abnormal lipid metabolism. The proatherogenic serum lipid profile is one of the factors for the high incidence of in these patients. The present study is done to assess alteration in lipid profile and its indices as cardiometabolic risk markers in psoriasis. Objectives: To evaluate lipid profile and lipid indices in psoriasis patients and appropriately matched age and sex healthy controls. To correlate between lipid indices and PASI score to assess cardiovascular risk in psoriasis patients. Methods: The present study is conducted in the Department of Biochemistry, at SNMC & HSK Hospital, Bagalkot. The study protocol is approved by the Institutional Ethical committee. The study includes 60 cases and 60 controls between 20-65 years. Lipid profile, Lp(a), Lipid indices are Atherogenic Index of Plasma (AIP), lipid tetrad index, Castelli's risk index– I, II, Atherogenic coefficient and non high– density lipoprotein cholesterol are calculated. Results: There was significant increase in total cholesterol, lowdensity lipoprotein cholesterol, non-highdensity lipoprotein cholesterol in psoriasis compared to controls. AIP and lipid tetrad index was significantly high compared to controls. AIP and non-high-density lipoprotein cholesterol showed a positive correlation with PASI score in psoriasis patients. Conclusion: Our results indicate that in psoriasis, there is severe dyslipidemia, which correlated positively with atherogenic index and non-high density lipoprotein cholesterol. Hence there is an increased cardiovascular risk in psoriasis patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|