Fox-Fordyce Disease in Two Prepubertal Girls: Histopathologic Demonstration of Eccrine Sweat Gland Involvement
| Autor: | Alicia Rositto, Ricardo Drut, Maria Ranalletta |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Keratinocytes
Fox–Fordyce disease Pathology medicine.medical_specialty Keratolytic Hyperkeratosis Dermatology Fox-Fordyce Disease Eccrine Glands Periareolar Lesion Keratolytic Agents Abdomen Biopsy medicine Humans Breast Eccrine sweat gland Child Umbilicus medicine.diagnostic_test business.industry Pruritus Puberty Apocrine Keratosis medicine.disease Apocrine Glands medicine.anatomical_structure Nipples Axilla Pediatrics Perinatology and Child Health Female medicine.symptom business Facial Dermatoses Neck Hair |
| Zdroj: | Pediatrics International. 13:294-297 |
| ISSN: | 1442-200X 1328-8067 |
| DOI: | 10.1111/j.1442-200x.1996.tb02870.x |
| Popis: | This report presents two prepubertal girls with Fox-Fordyce disease. The pruritic papules extensively affected the areas where apocrine glands are distributed (axillae, periareolar and intermammary zones, pubes, infraumbilical midline), and also extended to the neck and face near the external angle of the eyes in one child. Analyses of several biopsy specimens showed that the main lesion was a spongiotic vesicle containing inflammatory cells and keratinocytes affecting the hair infundibula and acrosyringia, together, with hyperkeratosis of both adnexa. The cause of the disease remains elusive, but the microscopic findings may explain the good results obtained with keratolytic agents. |
| Databáze: | OpenAIRE |
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