7-Nitro indazole, an inhibitor of neuronal nitric oxide synthase, attenuates pilocarpine-induced seizures
| Autor: | Redmer van Leeuwen, M.R. Dzoljic, René de Vries |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
medicine.medical_specialty Indazoles Central nervous system Mice Inbred Strains Motor Activity Nitric oxide Mice chemistry.chemical_compound Seizures Internal medicine medicine Animals Enzyme Inhibitors Pharmacology Indazole Dose-Response Relationship Drug biology Chemistry Pilocarpine Nitric oxide synthase medicine.anatomical_structure Endocrinology Enzyme inhibitor Excitatory postsynaptic potential biology.protein Neuron Nitric Oxide Synthase medicine.drug |
| Zdroj: | European Journal of Pharmacology. 287:211-213 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/0014-2999(95)00678-8 |
| Popis: | 7-Nitro indazole (25-100 mg/kg i.p.), an inhibitor of neuronal nitric oxide (NO) synthase, attenuated the severity of pilocarpine (300 mg/kg i.p.)-induced seizures in mice. This indicates that the decreased neuroexcitability of the central nervous system (CNS) following administration of 7-nitro indazole may be due to inhibition of neuronal NO synthase, implying that NO acts as an excitatory and proconvulsant factor in the CNS. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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