Psammomatous Cavernous Malformation Presenting as Drug-Resistant Epilepsy: Case Illustration and Review of Literature
| Autor: | James B. Pinskton, Christina Ledbetter, Peimin Zhu, John E. Shaughnessy, Nestor Dela Cruz, Piyush Kalakoti, Kanika Sharma, Hai Sun, Rosario Maria S. Riel-Romero, Anil Nanda, Rimal H. Dossani, Christina Notarianni, Eduardo Gonzalez-Toledo, Alireza Minagar |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Pathology medicine.medical_specialty Drug Resistant Epilepsy Hemangioma Cavernous Central Nervous System Psammoma body Adolescent Meningioma Lesion Diagnosis Differential 03 medical and health sciences Epilepsy 0302 clinical medicine medicine Humans Vascular Calcification Hyaline medicine.diagnostic_test business.industry Vascular malformation Magnetic resonance imaging medicine.disease 030104 developmental biology 030220 oncology & carcinogenesis Surgery Choroid plexus Neurology (clinical) medicine.symptom business |
| Zdroj: | World neurosurgery. 93 |
| ISSN: | 1878-8769 |
| Popis: | Background Psammoma bodies (PBs) are whorled, laminated hyaline spherules containing calcium deposits. Intracranially, the presence of PBs is associated with variants of meningioma and pituitary lesions, as well as aging choroid plexus. Limited information exists on their presence in vascular malformation. Results In this report, we describe a case of an adolescent male with drug-resistant epilepsy that was surgically managed at our regional epilepsy center. The epileptogenic focus was determined to be emanating from an indolent right insular lesion. Histopathologic evaluation showed the abundance of intravascular and perivascular PBs. Immunohistochemical evaluation confirmed the vascular origin using vascular markers. The unusual presence of PBs in a vascular lesion was unanticipated. Conclusions Based on our case, we present the clinicoradiologic characteristics, supplemented with intraoperative findings, for this unusual lesion. In addition, because of the unusual presence of PBs in vascular lesions, we provide the findings of a systematic literature review to show the association of PBs with intracranial vascular lesions. |
| Databáze: | OpenAIRE |
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