Impact of bulk and surface properties of some biocompatible hydrophobic polymers on the stability of methylene chloride-in-water mini-emulsions used to prepare nanoparticles by emulsification-solvent evaporation
| Autor: | Valery G. Babak, Omar Boulanouar, Frank Boury, Nathalie R. Kildeeva, Philippe Maincent, Francis Baros, Nathalie Ubrich, Michel Fromm |
|---|---|
| Přispěvatelé: | A. N. Nesmeyanov Institute of Organoelement Compounds (INEOS), Russian Academy of Sciences [Moscow] (RAS), Laboratoire Réactions et Génie des Procédés (LRGP), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de chimie physique et rayonnements (UMR E4) (LCPR), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Ingénierie de la vectorisation particulaire, Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Cibles thérapeutiques, formulation et expertise pré-clinique du médicament (CITHEFOR), Université de Lorraine (UL), Département de Chimie Physique des Réactions (DCPR), Institut National Polytechnique de Lorraine (INPL)-Centre National de la Recherche Scientifique (CNRS), INEOS RAS, Laboratoire de Mesures Nucléaires (LMN), Service Mesures et modélisation des Transferts et des Accidents graves (SMTA), Département Technologie Nucléaire (DTN), CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) (CEA-DES (ex-DEN)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) (CEA-DES (ex-DEN)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Département Technologie Nucléaire (DTN), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), MSTU (MSTU), Laboratoire de Pharmacie Galénique, Université Henri Poincaré - Nancy 1 (UHP) |
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Stability of mini-emulsions
Polymers Surface Properties Static Electricity Acrylic Resins Biocompatible Materials 02 engineering and technology Surface and zeta potentials Hydrophobic biocompatible polymers 010402 general chemistry 01 natural sciences Chloride chemistry.chemical_compound Colloid and Surface Chemistry Adsorption Polylactic Acid-Polyglycolic Acid Copolymer Phase (matter) Monolayer medicine Organic chemistry Lactic Acid Physical and Theoretical Chemistry Methylene chemistry.chemical_classification Methylene Chloride Spread monolayers Chemistry Cationic polymerization Water Surfaces and Interfaces General Medicine Polymer 021001 nanoscience & nanotechnology 0104 chemical sciences Solutions [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry PLGA Chemical engineering Solvents Nanoparticles Emulsions [PHYS.PHYS.PHYS-CHEM-PH]Physics [physics]/Physics [physics]/Chemical Physics [physics.chem-ph] 0210 nano-technology Interfacial tension Hydrophobic and Hydrophilic Interactions Polyglycolic Acid Biotechnology medicine.drug |
| Zdroj: | Colloids and Surfaces B: Biointerfaces Colloids and Surfaces B: Biointerfaces, Elsevier, 2007, 59 (2), pp.194-207. ⟨10.1016/j.colsurfb.2007.05.010⟩ Colloids and Surfaces B: Biointerfaces, Elsevier, 2007, 59 (2), pp.197-207. ⟨10.1016/j.colsurfb.2007.05.010⟩ Colloids and Surfaces B: Biointerfaces, 2007, 59 (2), pp.197-207. ⟨10.1016/j.colsurfb.2007.05.010⟩ |
| ISSN: | 0927-7765 |
| DOI: | 10.1016/j.colsurfb.2007.05.010⟩ |
| Popis: | International audience; The emulsifying and stabilizing ability of several hydrophobic (insoluble in water and soluble in volatile organic solvents) polymers, such as Eudragit RL, Eudragit RS, PLGA, PCL, and their mixtures, with regard to the methylene chloride (MC)-in-water mini-emulsions, has been compared to the viscosity of MC solutions and to the properties of adsorption and spread monolayers of these polymers. Eudragits RS and RL contain approximately 2.5 and approximately 5 mol% of pendent cationic trimethylammonium (TMA) groups per approximately 164 g/mol segments, whereas PLGA and PCL contain 1 and 2 polar carbonyl groups per 130 and 114 g/mol, respectively. The electrostatic attraction between the dipoles, formed by TMA groups and the condensed counter ions in the MC solutions, leads to the contraction of macromolecular coils of Eudragits, whereas the PLGA and PCL macromolecules, interacting by low polar carbonyl groups (with dipole moment mu = 2.7 D) retain more extended conformation in MC. This explains why the characteristic viscosities [eta] of MC solutions are much lower for the former polymers ( approximately 0.1 dL/g) with regard to PLGA and PCL solutions whose [eta] is equal to 0.3 and 0.6 dL/g, respectively. The ionization of TMA groups in contact with the water phase leads to the irreversible adsorption of Eudragits at the MC/water interface and to high decrease of the interfacial tension gamma (down to 4 mN/m for the 5% MC solutions). Whereas PLGA and PCL possessing low polar carbonyl groups adsorb poorly at the MC/water interface exhibiting gamma congruent with 28 mN/m. Higher stability of spread monolayers of Eudragits (pi* approximately 40 mN/m) with regard to PLGA and PCL (pi* < 20 mN/m) correlates well with higher interfacial activity of the former with regard to the later. The higher surface potential DeltaV of Eudragits (0.9 V) with regard to PLGA (0.3 V) and PCL (0.4V) is explained by the formation of electric double layer (DL) by the former, whereas the later contribute to the DeltaV only by cumulative dipole moments of carbonyl groups. The experimental values of surface potentials correlate well with the Gouy-Chapman model of the DL and the Helmholtz model of the monolayer. The ensemble of experimental results leads to the conclusion that higher emulsifying and stabilizing ability of Eudragits with regard to PLGA and PCL is due to higher adsorption activity of the former which form the corona of polymeric chains with ionized TMA groups around the droplets. It can be postulated that Eudragit polymers have good surface active properties which may allow manufacturing of biocompatible nanoparticles by emulsification-solvent evaporation method without surfactants. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect