Epstein-Barr virus-associated pneumonia and bronchiolitis obliterans syndrome in a lung transplant recipient
| Autor: | Albert Heim, Eberhard Straube, Renate Egerer, Roland Zell, Peter Wutzler, Andreas Sauerbrei, Martin Breuer, Angela Göhlert, Tim Sandhaus, Andi Krumbholz |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Microbiology (medical)
Adult Male Pathology medicine.medical_specialty Epstein-Barr Virus Infections Herpesvirus 4 Human Immunology Pneumonia Viral Bronchiolitis obliterans Biology Virus medicine Immunology and Allergy Humans Lymphocytes Respiratory system Bronchiolitis Obliterans Lung Transplantation Respiratory disease General Medicine medicine.disease Pneumonia medicine.anatomical_structure Respiratory failure RNA Viral Respiratory Insufficiency Respiratory tract |
| Zdroj: | Medical microbiology and immunology. 199(4) |
| ISSN: | 1432-1831 |
| Popis: | We report the case of a 25-year-old lung and liver transplant recipient who developed respiratory failure. High levels of Epstein-Barr virus (EBV) genome copies were detectable in respiratory tract specimens, while the search for various other viral, bacterial or fungal pathogens remained empty. Post-transplant lymphoproliferative disease was excluded. Due to the rapid progression of respiratory insufficiency, a re-transplantation of the lung was performed. EBV-encoded small RNAs could be demonstrated by in situ hybridization within pneumocytes and lymphocytes of the explanted lung tissue. The clinical situation improved soon after re-transplantation, and the EBV load detected in the lower respiratory tract decreased significantly. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink