Cell-of-origin classification by gene expression and MYC-rearrangements in diffuse large B-cell lymphoma of children and adolescents
| Autor: | Neus Masqué-Soler, Birgit Burkhardt, Reiner Siebert, Wolfram Klapper, Monika Szczepanowski, Sietse M. Aukema, Michael Altenbuchinger, Rainer Spang, Friederike Mahn, Jonas Lange, Thorsten Rehberg, Christian W. Kohler, Martin Zimmermann |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Adolescent Cell of origin Gene Expression Chromosomal translocation Biology Translocation Genetic Clonal Evolution Cohort Studies Proto-Oncogene Proteins c-myc 03 medical and health sciences 0302 clinical medicine immune system diseases Recurrence hemic and lymphatic diseases Gene expression medicine Biomarkers Tumor Humans In patient Paediatric age Child Hematology medicine.disease Lymphoma Gene expression profiling 030104 developmental biology 030220 oncology & carcinogenesis Child Preschool Cancer research Female Lymphoma Large B-Cell Diffuse Diffuse large B-cell lymphoma |
| Zdroj: | British journal of haematology. 179(1) |
| ISSN: | 1365-2141 |
| Popis: | Summary We present the largest series of diffuse large B-cell lymphoma (DLBCL) in patients younger than 18 years analysed to date by gene expression profiling using Nanostring technology to identify molecular subtypes and fluorescent in situ hybridization for translocations of MYC. We show that the activated B cell-like subtype of DLBCL is exceedingly rare in children and – in contrast to adults- not associated with outcome. Furthermore, we review the current literature and demonstrate that MYC translocations are not more frequent in paediatric compared to adult DLBCL. A prognostic role of MYC in the paediatric age groups seems unlikely. |
| Databáze: | OpenAIRE |
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