| Autor: |
Ozgur Albayrak, Bilge Kaan Kilicoglu, Cansel Vatansever, Mehmet Gönen, Fusun Can, Ozlem Dogan, Nazli Atac, Atalay Demiray, Onder Ergonul, Ozgun Ekin Sahin, Sercin Karahuseyinoglu |
| Rok vydání: |
2019 |
| Předmět: |
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| Popis: |
SummaryHere we proposed the hypothesis that hypervirulent colistin resistant K.pneumoniae (ColR-Kp) exhibit high number of virulence factors and have enhanced survival capacity against neutrophil activity.We studied virulence genes of ColR-Kp isolates and neutrophil response in 142 patients with invasive infections.The patients infected with hypervirulent ST101 and ST395 ColR-Kp had higher 30-day mortality (58%, p=0.005 and 75%, p=0.003, respectively. The yersiniabactin biosynthesis gene (ybtS) and ferric uptake operon associated gene (kfu) were significantly higher in ST101 (99%, p=+-ybtS+ ColR-Kp by neutrophils was significantly higher than kfu--ybtS- ColR-Kp (78% vs 65%, p+-ybtS+ ColR-Kp were more resistant to the killing activity of neutrophils than negative ones (7.90 vs 4.22; p=0.001). The kfu+-ybtS+ ColR-Kp stimulated excessive NET formation while the NET’s against kfu--ybtS- ColR-Kp were weak and rare.Iron uptake systems enhance successful survival of K.pneumoniae against neutrophil phagocytic defense, and stimulate excessive NET formation. The drugs targeted to iron uptake systems would be a promising approach for treatment of hypervirulent K.pneumoniae infections. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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